Ectopic calcification can cause pain and limit mobility. Studies suggest that circadian genes may play a role in the calcification process. Core circadian genes Clock, Npas2, and Bmal1 are transcription factors that form CLOCK:BMAL1 or NPAS2:BMAL1 transactivator complexes that drive the rhythmic expression of circadian oscillator genes and output genes. Circadian oscillator genes Period1-3 and ...

Background Osteoarthritis is a degenerative disease involving diarthrosis articulations. The evolution of the disease is very slow; the first changes regard the cellmatrix morpho-functional unit of articular cartilage called chondron by Benninghoff. The articular cartilage modifications are progressive from the superficial layer through the intermedial and the deep layer. Authors analyzed the u...

The clinical significance of cytoplasmic inclusions(CPI) in synovial fluid(SF) examination was evaluated. We examined SF specimens collected from major rheumatology clinics in the Philadelphia area during the period of January to December 1995. Among 759 patients in the initial study group, 419 cases with established diagnoses and full synovial analyses were included. Their diagnoses and SF ana...

Vertebral pathology has long been a useful criterion for anthropologists in the assessment of activity patterns, stress, and general health of extinct peoples. This method of analysis, however, has never been applied to the peoples of the Nebraska Great Plains. This study is the first to concentrate on the in­ digenous Native Americans of this region, examining the spinal pathology present in t...

BACKGROUND Degenerative joint disease most often affects middle-aged and elderly people. Patients over 65 years of age are frequently afflicted. The pain and limitation of mobility in joints are the cause of disability and reduced quality of life and lead to a decision to carry out total replacement surgery of the affected joint. Conservative treatment is often a palliative modality that genera...

Arthrosis is synonymous to osteoarthritis (OA) which is common degenerative disease of a joint in elderly and coxarthrosis specifically refer to hip joint osteoarthritis and it can be primary or secondary of which the latter due to other inflammatory joint disorders. Both arthrosis and arthritis shared some common clinical features such as pain and tenderness, stiffness and limited range of joi...

BACKGROUND Glycemic control is a known modifiable risk factor for diabetic foot disease. Prior attempts to define its relationship with diabetic foot ulcer and Charcot arthropathy fail to account for variability in control and duration of diabetic disease. We developed a novel metric to reflect aggregate disease exposure in a diabetic, termed cumulative glycemic burden. We hypothesized that it ...