Clear cell acanthoma or Degos' acanthoma is a distinct disease concerning its clinical, histopathological, and immunohistochemical features. Its pathologic nature - whether neoplastic or reactive - is still under dispute among researchers. The disease shows a chronic course and often presents with a single papulonodular lesion on the lower limbs of adults. However, cases with multiple lesions, ...

Abstract Background Degos disease is a rare vascular disorder with cutaneous-limited form, benign atrophic papulosis (BAP), and systemic variant, malignant (MAP). Despite the poor prognosis of MAP, no study has established features associated disease. Objectives The aims this systematic review were to: (1) summarize clinical treatments implemented for patients MAP BAP (2) identify laboratory fa...

Degos disease is an extremely rare disease, manifesting in the skin as necrotic papules. It may be skin-limited but prognosis poor for systemic involvement. primarily considered a microthrombopathy, pathophysiology remains elusive and lacks effective treatments. We found prominent lymphocytic infiltration targeting epidermis vasculature lesional of patients, suggesting immune-mediated pathophys...

Sir, Dowling-Degos disease (DDD) is a rare disorder characterized by acquired pigmented macules and papules in a reticulate pattern, particularly affecting the flexural areas and other major skin folds (1, 2). A female patient presented with dotted and reticulate pigmentation of the axilla, and was diagnosed as DDD both clinically and histopathologically. However, the asymmetrical distribution ...

Reticulate acropigmentation of Kitamura (RAK) and Dowling-Degos Disease (DDD) are rare genodermatosis inherited as an autosomal dominant trait with variable penetrance. They are part of a spectrum of diseases with hyperpigmented macules coalescing in a reticular pattern, facial and palmoplantar pits, breaks in dermatoglyphics, comedo-like lesions and epidermoid cysts, and a unique histological ...