Discovered gene regulation networks are very helpful to predict unknown gene functions. The activating and deactivating relations between genes and genes are mined from microarray gene expression data. There are evidences showing that multiple time units delay exist in a gene regulation process. Association rule mining technique is very suitable for finding regulation relations among genes. How...

conclusions a small diaphragmatic tear due to blunt trauma to the abdomen is difficult to diagnosis in acute settings due to ragged margins and possibly no herniated contents and usually present with a delayed complication. therefore a careful examination of the entire traumatized area is the best approach in treating delayed presentation of traumatic diaphragmatic hernia prior to development o...

the incidence of microbial keratitis after intacs implantation is extremely low and channel infection has been infrequently reported. we present a 23-year-old woman with keratoconus of both eyes who underwent implantation of two intrastromal corneal ring segments (intacs, keravision, inc., fremont, ca, usa) in the right eye. after 2.5 months, the patient presented with decreased vision, inflamm...

background: undescended testis (udt) is the most common endocrine disorder in male children. delayed diagnosis and treatment of udt lead to complications such as infertility, malignancy and testis rotation. objective: the aim of this study was to evaluate the causes of delay in proper treatment of patients with undescended testis in our population. materials and methods: an observational, descr...

Repeated low-dose morphine treatment facilitates delayed-escape behaviour of hippocampus-dependent Morris water maze and morphine withdrawal influences hippocampal NMDA receptor-dependent synaptic plasticity. Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes. We found that both delayed-escape behavi...

Gene expression and gene regulatory networks dynamics are stochastic. The noise in the temporal amounts of proteins and RNA molecules in cells arises from the stochasticity of transcription initiation and elongation (e.g., due to RNA polymerase pausing), translation, and post-transcriptional regulation mechanisms, such as reversible phosphorylation and splicing. This is further enhanced by the ...

Focal brain ischemia induces inflammation, extracellular matrix remodeling, gliosis, and neovascularization. Osteopontin (OPN) is a secreted glycoprotein that has been implicated in vascular injury by promoting cell adhesion, migration, and chemotaxis. To investigate the possible involvement of OPN in brain matrix remodeling after focal stroke, we examined the expression of OPN in ischemic cort...

BACKGROUND Fracture healing slows with age. While 6-week-old rats regain normal bone biomechanics at 4 weeks after fracture, one-year-old rats require more than 26 weeks. The possible role of altered mRNA gene expression in this delayed union was studied. Closed mid-shaft femoral fractures were induced followed by euthanasia at 0 time (unfractured) or at 1, 2, 4 or 6 weeks after fracture in 6-w...

OBJECTIVE Dynamically regulated expression of the gap junction protein connexin (Cx)43 plays pivotal roles in wound healing. Cx43 is normally downregulated and Cx26 upregulated in keratinocytes at the edge of the wound as they adopt a migratory phenotype. We have examined the dynamics of Cx expression during wound healing in diabetic rats, which is known to be slow. RESEARCH DESIGN AND METHOD...

Accumulating evidence supports the contention that CD4 and CD8 receptor molecules play a critical signaling role during thymocyte development. The lymphocyte-specific protein tyrosine kinase (p56lck), by virtue of its physical association with these surface components, provides a likely candidate for the biochemical signal transducing element required for these effects. To investigate the funct...