As a promising strategy for the successful regeneration of articular cartilage, tissue engineering has received increasing recognition of control release. Two kinds of functional poly (alanine ethyl ester-co-glycine ethyl ester) phosphazene microspheres with different ratios of side-substituent groups were synthesized by emulsion technique. The rate of degradation/hydrolysis of the polymers was...

Introduction . Articular cartilage has a limited intrinsic capacity for repair, therefore, methods to repair or reconstruct osteochondral defects have been sought by many labs (). The search for the ideal cellular matrix has resulted in the development and testing of both artificial and natural scaffold materials(). Current cellular scaffolds, however, are limited by the presence of inflammator...

INTRODUCTION Autogenous iliac crest bone graft continues to be the material of choice for posterolateral lumbar intertransverse process spine fusion. However, continued interest lies in developing bone graft alternatives that can be used as either graft extenders, graft enhancers, or graft substitutes. It was the purpose of this study to evaluate the efficacy of a demineralized bone matrix/ hya...

INTRODUCTION: Synthetic calcium phosphate cements (CPC) which mimic the chemical structure of the mineral composition of bone have been well accepted as bone grafting materials due to their consistent osteoconductivity, ease of use, and mechanical properties but are limited in application due to their lack of osteoinductive potential. Demineralized Bone Matrix (DBM) has also found significant a...

Despite the recapitulative nature of bone, a large percentage of nonunions still occur. Many exogenous substances have been administered to aid in the arthrodesis process, yet few have proven efficacious relative to time and cost. With recent advancements in bone biology involving cellular and molecular signaling, it is now possible to selectively retain bone progenitor cells from a patient’s b...

periodontal regeneration in a one-wall intrabony defect is a challenging and complex phenomenon. the combination therapy of commercially available bone grafts with the innovative tissue engineering strategy, the platelet rich plasma, has emerged as a promising grafting modality for two and three walled intrabony osseous defects. the application of this combination approach was attempted in a mo...

OBJECTIVES To evaluate the wound healing process following direct pulp capping with demineralized bone matrix (DBM) and calcium hydroxide (Ca(OH)2). METHODS Fifty 8-weeks-old SPF Wistar male rats were divided into two groups: one was the DBM treated group, and the other was the Ca(OH)2 treated group. Pulpotomy was performed on the maxillary first molar of one side of each rat, and the another...