نتایج جستجو برای: demyelination multiple sclerosis
تعداد نتایج: 789302 فیلتر نتایج به سال:
multiple sclerosis (ms) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by cd4+ t cells with a proinflammatory t helper (th)1 and th17 phenotypes, macrophages, and soluble inflammatory mediators. the overactive pro-inflammatory th1 cells and clonal expansion of b cells initiate an inflammatory cascade with several cellular and ...
multiple sclerosis (ms) is an autoimmune disease of the central nervous system (cns) which causes demyelination of the nerve fibers. the etiology of this disease is not well understood but it is believed that t helpers play a central role in ms. numerous findings support the view that th17 cells play an essential role in pathogenesis of ms and il-17 secreting t (th17) cells have a role in infla...
Introduction: Multiple sclerosis (MS) has been recognized as a common neurodegenerative disease that occurs after an Auto reactive T cells against myelin antigens. Demyelination and inflammation are the main features of this disease. The anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (BM-MSCs) have been considered as a suitable tre...
Background: The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system. It has been shown that green tea epigallocatechin-3-gallate (EGCG) might be effective in improving the symptoms and pathological conditions associated with autoimmune inflammatory diseases in several animal models. Object...
Multiple sclerosis is a chronic inflammatory disease with primary demyelination and neurodegeneration in the central nervous system. In our study we analysed demyelination and neurodegeneration in a large series of multiple sclerosis brains and provide a map that displays the frequency of different brain areas to be affected by these processes. Demyelination in the cerebral cortex was related t...
OBJECTIVE To validate the use of the magnetization transfer ratio (MTR) as a practical imaging marker of demyelination and remyelination in acute multiple sclerosis lesions. DESIGN Case study. SETTING University hospital multiple sclerosis clinic. Patients Six patients with relapsing-remitting multiple sclerosis and acute gadolinium-enhancing lesions were studied serially using a quantitati...
BACKGROUND AND PURPOSE Multiple sclerosis (MS) patients are often emotionally disturbed. We investigated anger in these patients in relation to demographic, clinical, and mood characteristics. PATIENTS AND METHODS About 195 cognitively unimpaired MS patients (150 relapsing-remitting and 45 progressive) were evaluated with the State Trait Anger Expression Inventory, the Chicago Multiscale Depr...
Introduction Magnetic resonance elastography (MRE) is an innovative imaging technique developed to non-invasively map and quantify the viscoelastic properties of tissue in vivo. MRE has been used as a tool to image and assess human tissue properties in several areas of the body such as breast tissue, prostate and skeletal muscle and brain. As pathological alterations cause changes in elasticity...
Multiple sclerosis is an autoimmune disease of the central nervous system characterized by inflammatory demyelination and axonal degeneration. It is the commonest cause of permanent disability in young adults. Environmental and genetic factors have been suggested in its etiology. Currently available disease modifying drugs are only effective in controlling inflammation but not prevention of neu...
In light of the published 2012 International Pediatric Multiple Sclerosis Group definitions for pediatric multiple sclerosis (MS) and related disorders and given that pediatric-onset MS is now formally included in the 2010 McDonald criteria for MS, we sought to review these criteria and summarize their application in children with acquired CNS demyelination. In addition, proposals are made for ...
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