The unique architecture of neurons requires the establishment and maintenance of polarity, which relies in part on microtubule-based kinesin motor transport to deliver essential cargo into axons and dendrites. In developing neurons, kinesin trafficking is essential for delivering organelles and molecules that are crucial for elongation and guidance of the growing axonal and dendritic termini. I...

Neuronal development and plasticity are maintained by tightly regulated gene expression programs. Here, we report that the developmentally regulated microRNA miR-375 affects dendrite formation and maintenance. miR-375 overexpression in mouse hippocampus potently reduced dendrite density. We identified the predominantly neuronal RNA-binding protein HuD as a key effector of miR-375 influence on d...

High-spatial resolution synchrotron X-ray imaging was combined with diffraction for a detailed investigation of FA mode solidification in Fe-Mn-Si (FMS) alloys during tungsten inert gas (TIG) spot welding. The sequence radiographs and patterns clearly revealed that the formation equiaxed γ-Fe dendrite occurred front growing columnar δ-Fe dendrites without any observable phases interdendritic re...

Deformation of the semisolid mush during solidification is a common phenomenon in metal casting and can lead to defects such as hot tears, macrosegregation, and porosity. The morphology of the solidifying mush, including the shape of the dendrites and the distribution of grain boundaries, plays a key role in determining its mechanical behavior. In the current study, a polycrystalline phase-fiel...

Dendrites are the primary sites on neurons for receiving and integrating inputs from their presynaptic partners. Defects in dendrite development perturb the formation of neural circuitry and impair information processing in the brain. Extracellular cues are important for shaping the dendritic morphogenesis, but the underlying molecular mechanisms are not well understood. In this study, we exami...

Eutectic structures in Ag-based brazing filler metals play an important role improving the properties of alloys and brazed joints. The typical microstructures morphological evolution Ag-Cu eutectic solidified at various cooling rates with addition different Sn contents were investigated. formation mechanisms anomalous structure (AES) transition from lamellar (LES) to AES elucidated. a slow rate...

Dendrites achieve characteristic spacing patterns during development to ensure appropriate coverage of territories. Mechanisms of dendrite positioning via repulsive dendrite-dendrite interactions are beginning to be elucidated, but the control, and importance, of dendrite positioning relative to their substrate is poorly understood. We found that dendritic branches of Drosophila dendritic arbor...

Lithium dendrite growth in Li-ion batteries is one of the most dangerous phenomena because it can cause inner short circuits and thermal runaways. However, nucleation dendrites are difficult to predict their complex behaviors, which depend on several factors such as charging conditions electrode-design parameters. In this study, a comprehensive mathematical model has been developed for Li-depos...