OBJECTIVES The aim of this study was to assess the clinical outcomes achieved with Computer-Assisted Design/Computer-Assisted Manufacturing implant abutments in the anterior maxilla. MATERIAL AND METHODS Nineteen patients with a mean age of 41 (range form 26 to 63) years, treated with 21 single tooth implants and 21 Computer-Assisted Design/Computer-Assisted Manufacturing (CAD/CAM) abutments ...

The generation of dental structures depends upon the manipulation of stem cells and requires a synergy of all cellular and molecular events that finally lead to the formation of tooth-specific hard tissues, dentin and enamel. Five different types of dental stem cells have been isolated from dental soft tissues: dental pulp, apical papilla, dental follicle and periodontal ligament. The character...

dental follicle derived cells showed enhanced osteoblastspecific genes and ectopic bone formation after in vivo transplantation, indicating dental follicle is the powerful stem cell source in bone tissue regeneration. Dental pulp is expected to harbor the pools of undifferentiated precursor cells for nerve or vascular tissue regeneration. The most powerful advantage of dental tissues as stem ce...

inhibiting T-helper cells while activating regulatory T-cells and suppressing B-lymphocytes. This immunomodulatory effect of MSCs makes them suitable for treatment of severe autoimmune diseases and graft-versus-host disease. However, most trials for the clinical application of MSCs have used bone marrow-derived MSCs (BMSCs). As mentioned previously, MSCs from dental tissue (DMSCs) exhibit simil...

Melatonin regulates a variety of biological processes, which are the control of circadian rhythms, regulation of seasonal reproductive function and body temperature, free radical scavenging and so on. Our previous studies have shown that various cells exist in human and mouse tooth germs that express the melatonin 1a receptor (Mel1aR). However, little is known about the effects of melatonin on ...

BACKGROUND After loss of natural teeth, provision of prosthodontic services almost becomes necessity in the present day living. To provide effective mastication teeth have peculiar forms. To make it more efficient both functionally and biologically, they are arranged in particular geometric manner referred to as dental arch. The objective of this study was to compare the distance between mesial...

objective: objective: dermal papilla and hair epithelial stem cells regulate hair formation and growth cycle. damage to or losing of these cells can cause hair loss. although several studies have claimed to reconstitute hairs using rodent cells in animal model, a stable human hair follicle reconstitution protocol needs more studies. here in this study we evaluated hair induction through injecti...

Wnt signaling is essential for tooth formation and Dact proteins modulate Wnt signaling by binding to the intracellular protein Dishevelled (Dvl). Comparison of the three known mouse Dact genes, Dact1-3, from the morphological initiation of mandibular first molar development through the onset of root formation using section in situ hybridization showed distinct, complementary and overlapping ex...