This study investigates the effectiveness of the antinociceptive effects of diclofenac, an NSAID, on the nociceptive behavior of morphine-treated rats on formalin test.Rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. The antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distil...

objective(s) studies have shown that morphine, in addition to its analgesic properties, has several effects on cell proliferation and apoptosis. there is also evidence that opioid receptors are present on chondrocytes. our main objective in the present study was to investigate the effects of morphine on rat femur growth cartilage. materials and methods this research was carried out on 18 4-week...

This study investigates the effectiveness of the antinociceptive effects of diclofenac, an NSAID, on the nociceptive behavior of morphine-treated rats on formalin test.Rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. The antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distil...

objective(s):to determine the effect of acetylcholine (ach), pilocarpine, and atropine on pain evoked responses of pain excited neurons (pen) and pain inhibited neurons (pin) in hippocampal ca3 region of morphine addicted rats. materials and methods:female wistar rats, weighing between 230-260 g were used in this study. morphine addicted rats were generated by subcutaneous injection of increasi...

  The effects of chronic morphine administration on the development of long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices using primed-bursts tetanic stimulation. Significant enhancement of orthodromic population spike (OPS) was found for all stimulus intensities after tetanic stimulation. OPS enhancement was great...

introduction: nowadays opioids are gaining acceptance for the management of moderate to severe and chronic pain. in addition, a number of studies have shown that plasma levels of β-endorphin (βep) in exercise trained are higher than sedentary rats. in our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. methods: male wistar rats (250±2...

objective(s): auraptene, a monoterpene coumarin from citrus species, exhibits cardioprotective effects.in this study, the effects of auraptene administration were investigated on blood pressure of normotensive and desoxycorticosterone acetate (doca) salt induced hypertensive rats. materials and methods: five weeks administration of auraptene (2, 4, 8 and 16 mg/kg/day) and nifedipine (0.25, 0.5,...