The marketing of selective serotonin reuptake inhibitors in the psychopharmacological industry presents a serious moral problem for the corporate model of medicine. In this paper I examine ethical issues relating to the efficacy and safety of these drugs. Pharmaceutical companies have a moral obligation to disclose all information in their possession bearing on the true risks and benefits of th...

OBJECTIVES To analyse the relation between selective serotonin reuptake inhibitor (SSRI) use and major congenital malformations, with focus on malformations of the heart. DESIGN Register-based retrospective nationwide cohort study, using the Danish Medical Birth Registry. SETTING Denmark. PARTICIPANTS Pregnant women in Denmark between 1997 and 2009 and their offspring. PRIMARY OUTCOME M...

BACKGROUND Adverse effects of antidepressants are most common at the beginning of the treatment, but possible also later. We examined the association between antidepressant use and work-related injuries taking into account the duration of antidepressant use. METHOD Antidepressant use and work-related injuries between 2000 and 2011 were measured among 66 238 employees (mean age 43.8 years, 80%...

Referências 1. Rowe DL. Off-label prescription of quetiapine in psychiatric disorders. Expert Rev Neurother. 2007;7(7):841-52. 2. Rachid F, Bertschy G, Bondolfi G, Aubry JM. Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases. J Clin Psychiatry. 2004;65(11):1537-45. 3. McIntyre A, Gendron A, McIntyre A. Quetiapine reduces residual depressive ...

A frontal lobe syndrome has previously been reported in adults treated with selective serotonin reuptake inhibitors (SSRIs), but not in children. Five typical cases of apathy and lack of motivation, one accompanied by disinhibition, are described in a child and four adolescents. Symptoms were dose related and reversible. The subtlety of symptoms, lack of insight in patients, disabling effects, ...

Hyponatremia complicates 1% of hospital admissions and can be associated with serious central nervous system effects. We report a case of a 38year-old woman with hyponatremia resulting in seizures and coma. Medications are one of many causes of hyponatremia. This case emphasizes the need to consider selective serotonin reuptake inhibitors (SSRIs) as a potential source of hyponatremia in all age...

BACKGROUND Use of antidepressants during pregnancy has been associated with a low Apgar score in infants but a contribution from the underlying depressive disorder might influence this association. AIMS To estimate the effects of maternal depression and use of antidepressants during pregnancy on low Apgar scores (<7) 5 min after birth. METHOD Register study on all pregnant women in Denmark ...

Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We...

Clinical impact ratings Mental health wwwwwwq Psychiatry wwwwwwq Paediatrics wwwwwwq GP/FP/Primary care wwwwwwq . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Q Are selective serotonin reupt...