Rapid advances in sequencing technologies set the stage for the large-scale medical sequencing efforts to be performed in the near future, with the goal of assessing the importance of rare variants in complex diseases. The discovery of new disease susceptibility genes requires powerful statistical methods for rare variant analysis. The low frequency and the expected large number of such variant...

KPNA3 is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between KPNA3 variation and schizophrenia. To investigate a wider role of KPNA3 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we...

aspergillus terreus is emerging as an etiologic agent of invasive aspergillosis among patients undergoing cancer chemotherapy, haematopoetic stem-cell transplantation, or solid organ transplantation worldwide. infections caused by aspergillus terreus has become important due to less susceptibility to antifungal drags, resistant to amphotericin b and therefore, poor clinical outcome and higher m...

We have prepared films of polymethyl .methacrylate in which fullerenes (a mixture of C,, and C,,) are uniformly embedded. By performing both degenerate four-wave mixing experiments and h-radiance-dependent transmission measurements with nanosecond laser pulses of 608nm wavelength, the third-order nonlinear optical susceptibility of these films is determined to be of the order of 10-l’ esu. This...

In anisotropic materials such as minerals and rocks, the AC magnetic susceptibility is also anisotropic, consists of two components, one in-phase with applied field (ipMS) other out-of-phase (opMS). Correspondingly, anisotropies these anisotropy (ipAMS) (opAMS), can be defined. non-conductive dia- paramagnetic materials, in pure multi-domain magnetite, opMS effectively zero only ipAMS measured....

Magnetic nanoparticle based hyperthermia emerged as a potential tool for treating malignant tumours. The efficiency of the method relies heavily on knowledge magnetic properties samples; in particular, frequency dependent complex susceptibility is vital to optimize irradiation conditions and provide feedback material science developments. We study frequency-dependent an aqueous ferrite suspensi...

It is known that many bacteria are susceptible to low pH, but it less clear how the acid nature influences this susceptibility. The objective of work was evaluate susceptibility selected different pH conditions and understand if their tolerance affected by type (organic vs inorganic) in media acidification. Strains species human pathogenic were cultivated at acidic conditions, using organic or ...