In this report the authors describe a woman with low-grade endometrial stromal sarcoma who was treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. After receiving megestrol acetate continuously for 19 years for chronic hormone suppression, she began to experience progressive dementia. Magnetic resonance imaging revealed 11 separate intracranial meningiomas of various ...

Why was this study done? Few studies have explored the utility of medical interventions in the management of uterine fibriods. A 2011 report by the Agency of Healthcare Research and Quality [1] concluded that the literature examining the effectiveness of treatment strategies was scanty. Gonadotropinreleasing hormone (GnRH) analogues, such as leuprolide acetate, have shown promise in the suppres...

the objective of this study was to evaluate three methods of estrous synchronization, viz. controlled internal drug releasing device (cidr), intravaginal sponges impregnated with fluogestone acetate (fga), and cloprostenol (estrumate; an analogue of prostaglandin f2α) in nadooshani goats of yazd province, iran.the estrous synchronized does (n = 30 to 33 per treatment), after heat detection, wer...

PIH33 Economic Evaluation of Ulipristal Acetate for the Treatment of Patients with Moderate and Severe Symptoms of Uterine Fibroids in Romania László Lorenzovici1*, Andrea Székely1, Tamás Ágh2, István Vámossy3, László Kelemen4, Hajnal Finta 5, Zoltán Kaló 6 1. Syreon Research Romania Ltd, Tirgu Mures, Romania; 2. Syreon Research Institute, Budapest, Hungary; 3. Gedeon Richter Plc, Budapest, Hun...

Transgender women are assigned male at birth but identified as women. The incidence of gender dysphoria is estimated to be around 1% the population. Gender may associated with depression and low quality life, which in most cases improves during gender-affirming hormonal treatment (GAHT). Feminizing for transgender or non-binary people typically includes natural estrogen (estradiol). Additional ...

BACKGROUND The endometrium becomes receptive to the embryo after sequential actions of estrogen and progesterone. The purpose of this study was to examine the effects of estrogen and progesterone on endometrial hemodynamics and on secretion of vascular endothelial growth factor (VEGF) from endometrial epithelial cells (EEC). METHODS Six early postmenopausal women taking sequential estrogen an...

Studies were conducted to evaluate the regulation of steroid production in dispersed cells from ovarian stromal tissue from 5- to 8-week-old-pullets (IM cells) and laying hens (MAT cells). Short-term incubation of IM and MAT cells with ovine (o) LH resulted in a dose-dependent increase in progesterone, androstenedione and oestradiol production; progesterone production was greater in MAT cells t...

It is well established that progestogens protect the endometrium against the proliferative effects of estrogens in postmenopausal women receiving hormone replacement therapy (HRT). Therefore, micronized progesterone and progestogens are recommended as part of combined HRT in women with an intact uterus. The protective effect of progestogens against hyperplasia and endometrial cancer does not ap...