BACKGROUND Oxygen desaturation during walking can have important consequence on prognosis of COPD patients. However, a standard 6-min walk test (6MWT), useful in detecting desaturation in COPD patients, can be difficult to execute in some settings of COPD management, as in the community healthcare service. We evaluated a new scoring system for the risk of oxygen desaturation during walking in C...

The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal preparations of rats has been studied. Administration of epinephrine (1 mg/kg body weight) produced a significant decrease in desaturation of [l-14C]=linoleic acid to gamma-linolenic acid and of [L-14C]alpha-linolenic acid to actadeca-6,9,12,15-tetraenoic acid 12 hr after the infection. Lower doses produc...

acid (EPA, 20 :5, n-3). In this study, we inyestigated the interaction of sesamin and EPA on A5 desaturation of both series and the n-61n-3 fatty acids ratio by measuring actural fatty acid contents in vivo. Rats vvere fed three types of dietary oils; 1) lino]eic a id (LA, 18:2, n-6); linolenic a id (LLA, 18:3, n-3)= 3:1, n-61n-3 ratio of 3:1 (LA group), 2) LA:LLA =1:3, n-6fn-3 ratio of 1:3 (LL...

BACKGROUND Sleep hypoxemia may change blood pressure by sympathetic activation. Few studies have analyzed blood pressure parameters in COPD patients who do not present sleep apnea, but do present sleep desaturation. OBJECTIVES To analyze blood pressure parameters in COPD patients with sleep desaturation not caused by apnea. METHODS Thirteen patients with COPD underwent spirometry, blood gas...

acid (EPA, 20 :5, n-3). In this study, we inyestigated the interaction of sesamin and EPA on A5 desaturation of both series and the n-61n-3 fatty acids ratio by measuring actural fatty acid contents in vivo. Rats vvere fed three types of dietary oils; 1) lino]eic a id (LA, 18:2, n-6); linolenic a id (LLA, 18:3, n-3)= 3:1, n-61n-3 ratio of 3:1 (LA group), 2) LA:LLA =1:3, n-6fn-3 ratio of 1:3 (LL...

AIMS To determine the prevalence of sleep-disordered breathing (SDB) in a clinical sample of overweight and obese children and adolescents, and to examine the contribution of fat distribution. METHODS Consecutive subjects without chronic lung disease, neuromuscular disease, laryngomalacia, or any genetic or craniofacial syndrome were recruited. All underwent measurements of neck and waist cir...

OBJECTIVE To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS Thirteen male patients with severe obstructive sleep apnea (mean age 43+/-10 years with a mean body mass index of 26.7+/-1.9 kg/m(2)) received a single 50-mg dose of sildenafil or a placebo at bedtime. All-night polysomnography and heart rate variability wer...

COPD patients have an increased prevalence of osteoporosis (OP) compared with healthy people. Physical inactivity in COPD patients is a crucial risk factor for OP; the COPD assessment test (CAT) is the newest assessment tool for the health status and daily activities of COPD patients. This study investigated the relationship among daily physical activity (DPA), CAT scores, and bone mineral dens...