Heterocyclic drugs can be cross-coupled with functionalized thiophene derivatives under dehydrogenative conditions using Pd-catalysts. Upon reductive desulfurization an alkyl linker is introduced with a functional group at its terminus, which will allow the immobilization of the drug molecule onto a solid support for chemical proteomics.

Introduction Environmental restriction regarding the quality of transportation fuels and the emissions from them are the most important issues. Because of more stringent regulations and fuel specifications regarding development of better method for deep-desulfurization of fuels are important. There has been recent interest in developing adsorbents for selective desulfurisation by adsorption. Me...

The HIV-1 Rev protein is responsible for shuttling partially spliced and unspliced viral mRNA out of the nucleus. This is a crucial step in the HIV-1 lifecycle, thus making Rev an attractive target for the design of anti-HIV drugs. Despite its importance, there is a lack of structural, biophysical, and quantitative information about Rev. This is mainly because of its tendency to undergo self-as...

N1-Substituted-6-arylthiouracils, represented by compound 1 [6-(2,4-dimethoxyphenyl)-1-(2-hydroxyethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one], are a novel class of selective irreversible inhibitors of human myeloperoxidase. The present account is a summary of our in vitro studies on the facile oxidative desulfurization in compound 1 to a cyclic ether metabolite M1 [5-(2,4-dimethoxyphenyl)-2,...

The study is focused on the determination of most effective chemical leaching process for simultaneous demineralization/deashing and desulfurization subbituminous coal from Bogovina Basin. Coal was treated 30 min, at different temperatures, using variable concentrations hydrochloric, nitric, acetic citric acids; hydrogen peroxide, mixture peroxide nitric acid (pH 2), as well by stepwise (nitric...

the performance of msu-s and its forms modified with phosphotungstic acid (hpw) and nickel (ni) for the desulfurization and denitrogenation of model diesel fuel were studied. according to the results of the characteristic tests (n2 adsorption-desorption, xrd, sem, and nh3-tpd), heteropoly acid incorporation causes higher acidity along with a negligible loss of structural aspects, while ni impre...

This research aimed to optimize the experimental conditions of biodesulfurization sulfide ore and evaluate flame-retardant effect after desulfurization under optimal conditions. Six factors were determined: particle size sample, ambient temperature, rotary speed shaking table, volume bacteria liquid, concentration leaching aid (Tween80), pH value acidizing sample. Desulfurization efficiency was...