Protein homeostasis is crucial to the health of living cells, and dysregulated protein homeostasis can trigger diseases, including cancer. Biochemical cell biologist Raymond Deshaies has devoted his distinguished career to the analysis of protein homeostasis and the development of therapeutic approaches to counter diseases that result when homeostasis goes awry. Deshaies has served as a profess...

This paper reviews three different types of challenges to adaptive control. The first group comprises challenges met in the subject’s development. They include difficulties associated with the MIT rule, bursting, the Rohr’s counterexample and unplanned instability in iterative identification and control. An understanding of these phenomena and mitigating strategies are now available. The second...

of most families. The holistic approach taken by Marshall is a welcome addition to the field, where work of a synthetic nature has been rare. Having access to all information in one place makes it far easier to see parallels in lifestyles and morphology among the diverse groups that make up the order. Flies is not only for keen dipterists, but is also of relevance to experimental biologists as ...

In Spain, gooseneck barnacles, “percebes,” are an overfished delicacy fetching a high market price ($50/lb). Oregon fishing communities show interest in developing a percebes market utilizing Pollicipes polymerus. We aim to inform resource managers to avoid over harvesting Oregon goosenecks. In summer 2016, we investigated the current status of P. polymerus populations with three primary object...

The views and opinions expressed in this publication are those of the authors and do not necessarily reflect those of the Australian Government or the Minister for the Environment and Heritage. Acknowledgments WWF-Australia would like to thank the Natural Heritage Trust and Department of Environment and Heritage for providing funding to key elements of the WWF Marine Debris Program over time. P...

The abstract and specific aims (described below) sections, two of the most important components of any grant application, must provide a cohesive framework for the application. The abstract provides an outline of the proposed research for the funding agency and the reviewers. Despite the fact that the abstract comes before the research plan in the physical document and is probably read before t...

Science Aims: • To achieve a major advance in the fidelity of simulations of the Global Environment by developing an Earth System Model with unprecedented resolution • To perform a ‘Grand Challenge’ multi-century simulation with the new Earth System Model, thus providing the NERC and wider UK science community with a unique resource for studying mechanisms of climate variability and change on t...

I can’t believe this is happening to me again. I find myself working on a grant when I wasn’t really planning on doing that this month, frantically re-writing and analyzing preliminary data in order to make the best case possible, to convince the NIH to give me funds for a new series of experiments. Why is it always like this? Why, every time I write a grant proposal, does the writing project g...

Co-oxidation is a little understood means of microbial degradation of petroleum hydrocarbons. In co-oxidation, microbes growing on one compound, the growth substrate, are able to oxidize a second · compound, the cosubstrate. This project examines the role of co-oxidation in the degradation of polycyclic aromatic hydrocarbons (PAR's), one of the most recalcitrant petroleum compounds now found in...

INTRODUCTION Low-level radioactive waste is the primary component of the toxic waste stream generated from biomedical research and patient care activities. Historically, this radioactive waste has been shipped to Richland, Washington for landfill disposal. Several years ago, the Nuclear Regulatory Commission "deregulated" liquid scintillation vials containing tritium and carbon 14. More recentl...