نتایج جستجو برای: dexrazoxane
تعداد نتایج: 227 فیلتر نتایج به سال:
An improved optimal drug scheduling model with considering two control drugs is proposed and the Gauss pseudospectral-based optimization method studied to decrease tumor size toxicity in this work. Firstly, Dexrazoxane drug, which has significant clinical effect reduce of anticancer introduced. By analyzing growth kinetics cancer chemotherapy, reduction regarded as second input dynamic equation...
Dexrazoxane [(DZR), ADR 529, ICRF-187] ameliorates doxorubicin (DOX)-induced cardiotoxicity in animals, and is recommended as a cardioprotectant in patients receiving cumulative doses of DOX above 300 mg/m2. A DZR:DOX dose ratio of 10:1 is recommended based on studies in patients receiving 50 mg/m2. Since DOX may be used at much higher doses in certain clinical settings, we evaluated the abilit...
A cardiotoxic effect induced by adriamycin (by repeated i.v. administration to experimental rats in 7-day intervals of administration) begins to be manifested in the ECG record by prolongation of the S alpha T segment between days 14 and 20, on day 30 it is statistically significant. By means of this index, the known protective effect of dexrazoxane (the preparation Cardioxan) against adriamyci...
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