introduction: walnut leaf contains large amounts of antioxidants, phenolic compounds and flavonoids and the beneficial effect of these compounds in the treatment of diabetes has been shown. this study investigated the effect of cyclohexane and ethanol extract of walnut leaf on activity of sorbitol dehydrogenase (sdh) enzyme. methods: fifty- six adult male sprague-dawley rats were divided into s...

Podocyte injury is an important mechanism of diabetic nephropathy (DN). Accumulating evidence suggests that nephrin expression is decreased in podocyte in DN. Moreover, it has been demonstrated that tongxinluo (TXL) can ameliorate renal structure disruption and dysfunction in DN. However, the effect of TXL on podocyte injury in DN and its molecular mechanism is unclear. In order to explore the ...

results the data revealed that self-efficacy (p < 0.001) and social support (p < 0.001) are indicators than can significantly anticipate levels of adjustment in diabetic patients. moreover, it has been revealed that self-efficiency plays a significant and, indeed, fundamental role in adjustment anticipation. conclusions it can be concluded that self-efficacy and social support are important in ...

background: resveratrol has beneficial effects on cardiovascular system. this study aimed at examining antidiabetic and antihypertensive effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension. methods: eight groups (8-10 each) of male spargue-dawley rats, including a control, a diabetic (induced by streptozotocin and nicotinamide), a renal hypertensive (induced ...

angiotensin-converting enzyme (ace) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. the present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (stz)-diabetic rats treated for 4 weeks with nitro-l-arginine-methyl ester (l-nam...

The nature and mechanism of the pancreatic exocrine dysfunction in diabetes mellitus were evaluated in vitro using isolated pancreatic acini prepared from streptozotocin-induced diabetic rats. The content of amylase and ribonuclease in diabetic acini was approximately 0.5 and 50% of the normal content, respectively. Further, reduced amounts of both enzymes were secreted by diabetic acini in res...

To evaluate the roles of hyperglycemia and increased plasma FFA level in the development of insulin resistance, we examined the effects of phlorizin and acipimox treatments on tissue sensitivity to insulin in streptozotocin(STZ)-diabetic rats. Insulin sensitivity was assessed with the glucose-insulin clamp technique. Blood glucose concentration was clamped at basal levels of control and diabeti...

Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The present study investigates the effects of diabetes induced by streptozotocin (STZ) o...