Amide-amide NOESY provides important distance constraints for calculating global folds of large proteins, especially integral membrane proteins with beta-barrel folds. Here, we describe a diagonal-suppressed 4-D NH-NH TROSY-NOESY-TROSY (ds-TNT) experiment for NMR studies of large proteins. The ds-TNT experiment employs a spin state selective transfer scheme that suppresses diagonal signals whil...

alzheimer’s disease (ad) is a uniquely human disorder. although the pathogenesis of ad is not fully understood, growing evidence indicates that the deposition of beta-amyloid (aβ) and the local reactions of various cell types to this protein play major roles in the development of the disease. in the present study transgenic mice expressing mutant amyloid precursor protein (app) has been used. t...

It is well-known how any symmetric matrix can be transformed into a similar tridiagonal one [1, 2]. This orthogonal similarity transformation forms the basic step for various algorithms. For example if one wants to compute the eigenvalues of a symmetric matrix, one can rst transform it into a similar tridiagonal one and then compute the eigenvalues of this tridiagonal matrix. Very recently an a...

The motor rehabilitation is based on exercises that involve various joints and muscle groups. One such treatment method is Proprioceptive Neuromuscular Facilitation (PNF), which involves diagonal movements simulating many activities of daily living. The objective of this study was to investigate the differences between PNF and shoulder flexion movements performed without the diagonal component ...

SUPPLEMENTARY FIGURE S1 ROC plots illustrating the Wormnet-based prediction of RNAi phenotypes. For each known phenotype, we analyzed the ability to predict genes conferring the phenotype using leave-one-out analysis. Every gene in the Wormnet was first rank-ordered by the sum of its LLS scores to all other genes with the given RNAi phenotype; we then measured the recovery of genes with the giv...

In some applications the covariance matrix of the observations is not only symmetric with respect to its main diagonal but also with respect to the anti-diagonal. The standard forward-only sample covariance estimate does not impose this extra symmetry. In such cases one often uses the so-called forward-backward sample covariance estimate. In this paper, a direct comparative study of the relativ...

A MacMahon symmetric function is a formal power series in a finite number of alphabets that is invariant under the diagonal action of the symmetric group. In this article, we show that the MacMahon symmetric functions are the generating functions for the orbits of sets of functions indexed by partitions under the diagonal action of a Young subgroup of a symmetric group. We define a MacMahon chr...

This paper presents an optimal solution for amplify-and-forward (AF) single-input multiple-output (SIMO) and multiple-input single-output (MISO) wireless distributed relay networks. The optimal solutions are determined based on minimum mean square error (MMSE) criterion for optimum nondiagonal and diagonal relay amplifying matrices under the transmit power constraints at the relays. The bit err...

We study Anderson localization in two-dimensional systems with purely off-diagonal disorder. Localization lengths are computed by the transfer-matrix method and their finite-size and scaling properties are investigated. We find various numerically challenging differences to the usual problems with diagonal disorder. In particular, the divergence of the localization lengths close to the band cen...

1. The algorithm. Huang [1] gives an algorithm for computing the powers of a triangular matrix where the diagonal elements are unique. However, in contrast to Huang’s algorithm, the method presented here has the unique advantage of producing the result in closed form, which shows explicitly how the behavior of any element of the matrix varies with varying powers of the matrix. Also, the closed ...