channel activities, particularly those of calcium channels, have vital roles in the process of sperm maturation, motility and sperm-egg interaction. a group of the recently discovered ion channels associated with these processes is four novel channel-like proteins known as catsper (cation channel sperm) gene family. catsper1 and catsper2 show sperm specific expression patterns. however, neither...

background: linum album, a herbaceous and medicinal plant, has been shown to accumulate anti-tumor podophyllotoxin (ptox) and related lignans. objective: in this study, we have verified the time-course of cell growth, lignan production in cells treated with chitosan and chitin oligomers. to study mechanism of chitosan and chitin oligomers action, expression of phenylalanine ammonio-lyase (pal),...

background: toxoplasmosis is a worldwide-distributed infection which is mostly asymptomatic but can cause serious health problems in congenitally-infected newborns and immunecompromised individuals. research is undergoing both to improve toxoplasma serological tests, which play the main role in laboratory diagnosis of the infection, and develop an effective vaccine to prevent the infection. som...

expression of receptor tyrosine kinase ror1 in a wide variety of cancers has emerged as a new era focusing on targeting this receptor in cancer therapy. our preliminary re-sults indicate the presence of a truncated transcript of ror1 in tumor cells. the trun-cated ror1 encompasses extracellular and transmembrane domains, lacking catalytic kinase domain (ror1-ecd). as enzyme activity is highly d...

chicken has been used as a suitable model for lipid metabolism studies, because dietary modifications especially dietary fat type can change chicken body composition. fats act as a condense source of energy and certain fatty acids such as polyunsaturated fatty acids (pufas) are required for both animal and human health. the n-3 pufas, especially, eicosapentaenoic acid (epa) and docosahexaenoic ...

background: this study aimed to compare the cytochrome p450 1a1 (cyp1a1) gene expression in the cord blood of infants born from mothers living in low- and high-air polluted areas. materials and methods: te study was conducted in spring 2012 in isfahan, the second large and air-polluted city in iran. the study comprised 60 neonates, consisting of 30 infants born from mothers residing in areas wi...

Background: Acute myeloid leukemia (AML) is a dangerous type of leukemia. The emergence multidrug resistance (MDR) and recurrence limits the prognosis survival patients. In recent studies, we have known that bone marrow microenvironment was closely related to poor AML. However, underlying mechanisms are still far from fully understood. By utilizing bioinformatics analysis, screened out integrin...

background and objectives: phosphlipases are a group of enzymes that breakdown phosphatidylcholine (phospholipids) molecules producing second products. these produced products have a divers role in the cell like signal transduction and digestion in humans. in this research the effect of phosphatidylcholine on the expression of plc genes of a. fumigatus was studied. the plc genes of this fungus ...

Background: The Wilm’s tumor gene 1 (WT1) encodes a zinc finger transcription factor that is inactivated in a subset of Wilm’s tumors. It plays a crucial role in growth, proliferation and development of some embryonic and adult organs. WT1 is expressed as a tumor associated antigen (TAA) in various types of solid and hematopoietic malignancies and can be employed as a useful marker for targeted...