The large number of reagents that have been developed for the synthesis of trifluoromethylated compounds is a testament to the importance of the CF3 group as well as the associated synthetic challenge. Current state-of-the-art reagents for appending the CF3 functionality directly are highly effective; however, their use on preparative scale has minimal precedent because they require multistep s...

Metal-ligand cooperation (MLC) plays an important role in bond activation processes, enabling many chemical and biological catalytic reactions. A recent new mode of activation of chemical bonds involves ligand aromatization-dearomatization processes in pyridine-based pincer complexes in which chemical bonds are broken reversibly across the metal centre and the pincer-ligand arm, leading to new ...

Alkene hydrosilylation, the addition of a silicon hydride (Si-H) across a carbon-carbon double bond, is one of the largest-scale industrial applications of homogeneous catalysis and is used in the commercial production of numerous consumer goods. For decades, precious metals, principally compounds of platinum and rhodium, have been used as catalysts for this reaction class. Despite their widesp...

Using asymmetric catalysis to simultaneously form carbon-carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely applicable enantioselective Suzuki-Miyaura variations to provide 3D molecules re...

Previous studies from this laboratory have shown that rat uterine homogenates contain a reduced pyridme nucleotide oxidase which is activated by ‘2,4-dichlorophenol and other phenolic substances (1, 2). Oophorectomy reduces the activity of this enzyme system to negligible levels but prompt restoration of the oxidative rate was observed upon the administration of small amounts of estradiol to th...

Ehsan Noroozizadeh was born in Dezful/Khoozestan, Iran. He received his B.S. in Pure Chemistry (2011) and M.S. in Organic Chemistry (2013) from Bu-Ali Sina University, Iran. He is currently working towards his Ph.D. under the supervision of Professor Mohammad Ali Zolfigol. His research interest is catalysis, including the application of homogeneous and heterogeneous catalysis in organic synthesis.

Mahmoud Zarei was born in Hamedan, Iran in1986. He received his B.Sc. in Pure Chemistry (2010) from Islamic Azad University Arak and M.Sc. in Organic Chemistry (2013) at Bu-Ali Sina University, Iran. He is currently working towards his Ph.D. under the supervision of Professor Mohammad Ali Zolfigol. His research interest is catalysis, including the application of homogeneous and heterogeneous ca...

For sustainable application of chloroprene rubber (CR), a new technology is developed by the vulcanization CR using 2,2’-dithiodipyridine (DPD) as cross-linking agent with reprocessing performance owing to disulfide metathesis. When DPD was incorporated into vulcanization, Menschutkin reaction between allyl chloride group and pyridine occurred maximum exothermic peak at 184°C. The number effect...

In this study, which incorporates many principles of green chemistry (use renewable feedstocks, catalysis, improvement energy efficiency, and harmless solvents auxiliaries), the single-phase catalytic conversion cellulose to 5-HMF in over silica-alumina catalysts was investigated. A series dual-template with CTAB as main template F127 or triethylamine (TEA) co-template were synthesized at a low...

Cytochrome P450 CYP17A1 catalyzes a series of reactions that lie at the intersection of corticoid and androgen biosynthesis and thus occupies an essential role in steroid hormone metabolism. This multifunctional enzyme catalyzes the 17α-hydroxylation of Δ4- and Δ5-steroids progesterone and pregnenolone to form the corresponding 17α-hydroxy products through its hydroxylase activity, and a subseq...