Dimethylamine was formed from trimethylamine in soils of different pH values. The rate of disappearance of the secondary amine from soil was affected by pH and was markedly reduced under anaerobiosis. The accumulation of dimethylamine in cultures of Micrococcus sp. provided with trimethylamine depended on the nitrogen sources available to the bacterium but was not greatly influenced by the C-N ...

Epithelial-like cells from rat liver were exposed in cell culture to aflatoxin BI, dimethylnitrosamine, 7V-nitrosomethylurea, jV-hydroxy-Af-2-fluorenylacetamide, or 7,12dimethylbenz(a)anthracene. Microscopic observation revealed several morphological changes in almost all of the treated sublines but revealed no uniform, characteristic alterations common to all of the cultures. The injection of ...

A major and previously undetected carcinogen-DNA adduct was found in the livers of rats given N,N-dimethylnitrosamine or 1,2-dimethylhydrazine. This adduct, which accounted for 55% of the total methyl residues in DNA at 72 hours after carcinogen treatment, was chromatographically identical to a synthetic purine ring-opened derivative of 7-methylguanine and could be released from the isolated he...

The effect of age at treatment on the incidence and type of kidney tumor induced by dimethylnitrosamine was investigated in an established model of experimental renal carcinogenesis. Groups of Potion albino Wistar rats were dosed with carcino gen at 24 hr; at 3 weeks; and at i , i .5, 2, 3, 4, and 5 months of age. In all groups except the neonates, the animals were preconditioned by feeding a n...