structural repetitive subsequences are most important portion of biological sequences, which play crucial roles on corresponding sequence’s fold and functionality. biggest class of the repetitive subsequences is “transposable elements” which has its own sub-classes upon contexts’ structures. many researches have been performed to criticality determine the structure and function of repetitive su...

Managing and delivering virtualised cloud-based services in systems like the virtual computing lab (VCL) is an open challenge. Current research is focused on enhancing specific components like service discovery, composition and monitoring and there is no holistic view of what would constitute a lifecycle of virtualised services delivered on a cloud environment. We have developed a policy-based ...

Virtual screening is an important step in early-phase of drug discovery process. Since there are thousands of compounds, this step should be both fast and effective in order to distinguish drug-like and nondrug-like molecules. Statistical machine learning methods are widely used in drug discovery studies for classification purpose. Here, we aim to develop a new tool, which can classify molecule...

Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a r...

Natural products (NPs) continue to play a pivotal role in drug discovery programs. The rapid development of synthetic biology has conferred the strategies of NPs production. Synthetic biology is a new engineering discipline that aims to produce desirable products by rationally programming the biological parts and manipulating the pathways. However, there is still a challenge for integrating a h...

The Mobile Web promises a new age of anytime, anywhere information access to billions of users across the globe. However, the Mobile Internet represents a challenging information access environment, particularly from a search standpoint. In this paper we present two visual interfaces for improved mobile search. First, we present SearchBrowser, a map-based interface that offers richer end-user i...

In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...

Three-dimensional (3D) pharmacophore modeling is a technique for describing the interaction of a small molecule ligand with a macromolecular target. Since chemical features in a pharmacophore model are well known and highly transparent for medicinal chemists, these models are intuitively understandable and have been increasingly successful in computational drug discovery in the past few years. ...

Background. Physical education learning in the era of the COVID-19 pandemic has a remarkable impact on students’ creativity. Objectives. This study aims to determine the effect of applying the inquiry and discovery models in online physical education learning to develop high school students’ creativity. Methods. The multiple treatment and control with the pre and post-test procedure were used...