BACKGROUND In order to identify patients who would benefit from prophylactic amtiemetics, six predictive models have been described for the risk assessment of postoperative nausea and vomiting (PONV). This study compared the validity and practicability of these models in patients undergoing general anaesthesia. METHODS Data were analysed from 1566 patients who underwent balanced anaesthesia w...

The establishment of biorelevant and discriminating dissolution procedure for drug products with limited water solubility is a useful technique for qualitative forecasting of the in vivo behavior of formulations. It also characterizes the drug product performance in pharmaceutical development. Lornoxicam, a BCS class-II drug is a nonsteroidal antiinflammatory drug of the oxicam class, has no of...

Future Cosmic Microwave Background (CMB) experiments will deliver extremely accurate measurements of the E-modes pattern CMB polarization field. Given sharpness transfer functions, such surveys make for a powerful detector high-frequency signals from primordial features that may be lurking in current data sets. With handful toy models increase fit to latest Planck data, but are marginal statist...

UNLABELLED Acute, severe hypovolemia is a medical emergency. Traditional vital sign parameters allow no optimal triage. High predictive power of finger plethysmography-based stroke volume (SV) and pulse pressure (PP) was recently suggested. To assess the performance of the PP and SV parameters, lower body negative pressure of -40 mmHg, than -60 mmHg - corresponding to moderate and severe centra...

Several risk scores have been developed to calculate the probability of postoperative nausea and vomiting (PONV). However, the power to discriminate which individual will suffer from PONV is still limited. Thus, we wondered how the number of predictors in a score affects the discriminating power and how the characteristics of a population--which is needed to measure the power of a score--may af...

the increase in the number of producers and manufacturers leads to various methods of attracting customers. one of the appropriate ways to attract customers is to provide them with post-sale support. to guarantee the quality of a product is one of the services according to which the seller is committed to change the problematic product. to analyze the legal aspects of guarantee makes it necessa...