In this study the properties of poly(D,L-lactide-co-glycolide) (PLGA) dispersions containing a thermoresponsive cationic copolymer were investigated. The PLGA dispersions were prepared by interfacial deposition in aqueous solution and were rendered thermoresponsive by addition of a cationic poly(N-isopropyl acrylamide) (PNIPAm) graft copolymer. The copolymers used had the general composition PD...

It was reported that cilostazol (CLZ) suppressed disruption of the microvasculature in ischemic areas. In this study, we have designed novel injection formulations containing CLZ nanoparticles using 0.5% methylcellulose, 0.2% docusate sodium salt, and mill methods (CLZnano dispersion; particle size 81 ± 59 nm, mean ± S.D.), and investigated their toxicity and usefulness in a cerebral ischemia/r...

PURPOSE Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion. METHODS Spironolactone solid dispersions (1:1, 1:2 and 2:1 drug: carrier weight ratio) were prepared by polyethylene glycol (PEG) 6000 as a carrier by hot melt...

In t h i s paper we b r i e f l y p resen t t h e main re levan t physical q u a n t i t i e s i n t h e rheology of concentrated d i spers ions . Main l i n e s o f t h r e e t o p i c s ( s h e a r v i scos i ty , sedimentation ve loc i ty and aggregation processes) a r e then given. The importance o r ordered or random s t r u c t u r e s is emphasized. Nature and i n d u s t i a l processes...

Conventional quantum uncertainty relations (URs) contain dispersions of two observables. Generalized URs are known which contain three or more dispersions. They are derived here starting with suitable generalized Cauchy inequalities. It is shown what new information the generalized URs provide. Similar interpretation is given to generalized Cauchy inequalities. key words: quantum mechanics, unc...