نتایج جستجو برای: dn
تعداد نتایج: 7049 فیلتر نتایج به سال:
TCRalphabeta+CD4-CD8- double-negative (DN) T regulatory (Treg) cells have recently been shown to suppress Ag-specific immune responses mediated by CD8+ and CD4+ T cells in humans and mice. Our previous study using cDNA microarray analysis of global gene expression showed that FcRgamma was the most highly overexpressed gene in functional DN Treg cell clones compared with nonfunctional mutant clo...
Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protein-1 (sXBP1) is selectively impaired in DN, inducing activating transcription factor-6 (ATF6) and ...
در این کار تحقیقاتی ابتدا مطالعه سینتیک واکنش پیریدین و 2 کلر پیریدین با کمپلکس پلاتین (ii) به فرمول p-tol)2 (sme2)2])pt]در دماهای 30،20،15،5 و 40 درجه سلسیوس بررسی گردید. که بدلیل سرعت زیاد واکنش محاسبه پارامترهای سینتیکی غیر میسر بود لذا کار ترمودینامیکی جانشینی سه لیگاند از پیریدین و مشتقات آن (2 کلروپیریدین و 2 برموپیریدین) در سه حلال (دی کلرو متان، استن و متانول) در دستور کار قرار گرفت. ب...
BACKGROUND Diabetic nephropathy (DN) is a major cause of chronic kidney failure and characterized by excessive deposition of extracellular matrix. Evidence have shown that transforming growth factor-β1 (TGF-β1) is a key mediator in the development of DN. However, treatment of DN by blocking the TGF-β1/Smad7 pathway remains limited. Xiaokeping mixture (XKP), a traditional Chinese herbal compound...
The function of sensory hair cells of the cochlea and vestibular organs depends on an influx of K(+) through apical mechanosensitive ion channels and its subsequent removal over their basolateral membrane. The KCNQ4 (Kv7.4) K(+) channel, which is mutated in DFNA2 human hearing loss, is expressed in the basal membrane of cochlear outer hair cells where it may mediate K(+) efflux. Like the relate...
Methods that infer site-specific dN/dS, the ratio of nonsynonymous to synonymous substitution rates, from coding data have been developed primarily to identify positively selected sites (dN/dS > 1). As a consequence, it is largely unknown how well different inference methods can infer dN/dS point estimates at individual sites. In particular, dN/dS may be estimated using either a one-rate approa...
Glypican-3 (GPC3) has been reported to be a novel serum and histochemical marker for HCC. The positivity or negativity for GPC3 in hepatic precancerous lesions, such as dysplastic nodules (DN), has also been described. Moreover, our previous studies have demonstrated that some DN in liver cirrhosis represent monoclonal hyperplasia, and confirmed their neoplastic nature. However, additional stud...
In this paper we study the branching problems for Hecke algebra H(Dn) of type Dn. We explicitly describe the decompositions of the socle of the restriction of each irreducible H(Dn)-representation to H(Dn−1) into irreducible modules by using the corresponding results for type B Hecke algebras. In particular, we show that any such restrictions are always multiplicity free.
Objectives The aim of this study was to observe the impact of sirolimus on proteinuria in streptozotocin (STZ) induced diabetic rats. Materials and Methods Rats were given a single injection of STZ to induce diabetic rat model. Rats' 24 hr urine was collected to test, urinary and the kidney tissues were harvested at the 8th and 20th weeks, respectively. Podocyte morphological changes were exa...
We discuss an embedding of su(n) rank two antisymmetric supercharges in the su(2, 2|dn) superalgebra, where dn = n(n − 1)/2. describe algorithm to construct explicit form generators superalgebra.
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