Background: Assessment of DNA profile quality is vital in forensic DNA analysis, both in order to determine the evidentiary value of DNA results and to compare the performance of different DNA analysis protocols. Generally the quality assessment is performed through manual examination of the DNA profiles based on empirical knowledge, or by comparing the intensities (allelic peak heights) of the...

The goal of this paper is to determine the braid index of two types of complicated DNA polyhedral links introduced by chemists and biologists in recent years. We shall study it in a more broad context and actually consider so-called Jaeger's links (more general Traldi's links) which contain, as special cases, both four types of simple polyhedral links whose braid indexes have been determined an...

Flow cytometric DNA-index (DI(FCM)) and karyotype were analysed in 82 consecutive children with acute lymphoblastic leukemia (ALL) during a 10 year period. A statistically significant correlation existed between modal chromosome number and DI(FCM) (p = 0.009). DI(FCM) could reliably identify leukemias with >51 chromosomes, whereas only three out of 12 cases with modal chromosome numbers between...

The growing interest in genomic research has caused an explosive growth in the size of DNA databases making it increasely challenging to perform searches on them. In this paper, we proposed an index structure called the ed-tree for supporting fast and effective homology searches on DNA databases. The ed-tree is developed to enable probe-based homology search algorithms like Blastn which generat...

Due to its longevity and enormous information density, DNA is an attractive medium for archival storage. In this work, we study the fundamental limits trade-offs of DNA-based storage systems by introducing a new channel model, which call noisy shuffling-sampling channel. Motivated current technological constraints on synthesis sequencing, model captures three key distinctive aspects systems: (1...

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The advancement of technology in scientific community has produced terabytes of biological data. This datum includes DNA sequences. String matching algorithm which is traditionally used to match DNA sequences now takes much longer time to execute because of the large size of DNA data and also the small number of alphabets. To overcome this problem, the indexing methods such as suffix arrays or ...

A cell culture system has been utilized to measure the effects of drugs on DNA synthesis in uninfected and HSV-(herpes simplex virus)-infected KB cells. DNA from HSV-infected cells was separated into viral and cellular components by isopycnic centrifugation in CsCl gradients. The amount of [3H]thymidine incorporated into acid-insoluble material was measured in the absence and presence of drugs....