نتایج جستجو برای: dna radioprotection

تعداد نتایج: 507977  

2013
Anupam Chatterjee

The tripeptide glutathione (GSH) is the most abundant intracellular nonprotein thiol, and it is involved in many cellular functions including redox-homeostatic buffering. Cellular radiosensitivity has been shown to be inversely correlated to the endogenous level of GSH. On the other hand, controversy is raised with respect to its role in the field of radioprotection since GSH failed to provide ...

Journal: :International journal of molecular sciences 2018
Martyna Śniegocka Ewa Podgórska Przemysław M Płonka Martyna Elas Bożena Romanowska-Dixon Małgorzata Szczygieł Michał A Żmijewski Mirosława Cichorek Anna Markiewicz Anna A Brożyna Andrzej T Słominski Krystyna Urbańska

The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption as mechanisms of melanin radioprotection. Experimental models of melanoma in hamsters and in gerbils are described as well as their use in bio...

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