The use of marine n-3 polyunsaturated fatty acids (n-3 PUFA) as supplements has prompted the development of concentrated formulations to overcome compliance problems. The present study compares three concentrated preparations - ethyl esters, free fatty acids and re-esterified triglycerides - with placebo oil in a double-blinded design, and with fish body oil and cod liver oil in single-blinded ...

Psoralea corylifolia is the most important medicinal plant which has various secondary metabolites and its leaves are broadly used in many sectors due to antimicrobial activity. This study aimed find bio-active compounds of chloroform extract P. using Perkin-Elmer Gas Chromatography – Mass Spectrometry (GC-MS). The results GC-MS was appropriate database National Institute Standards Technology (...

Novel routes for the preparation of 2-amino-4H-pyran-3-carbonitrile 9, amino-arylbenzoic acid ester derivatives 13a,b, 2-aminotetrahydro-4H-chromene-3-carbonitrile 18, 3-amino-4-cyanotetrahydronaphthalene-2-carboxylic acid ester 26 and 4-amino-3,5-dicyanophthalic acid ester derivatives 37a-c were developed. The synthetic methods utilize one-pot reactions of acetylene carboxylic acid esters, α,β...

The muscarinic receptor mediating vasodilation of resistance vessels in the rat isolated, constant-pressure perfused kidney (preconstriction by 10(-7) M cirazoline) was characterized by subtype-preferring agonists and selective antagonists. The agonists produced vasodilation with the following rank order of potency: arecaidine propargyl ester (APE) > 5-methylfurtrethonium = methacholine = oxotr...

A mast cell protease has been purified over 260-fold from rat thyroid homogenates. The purified enzyme hydrolyzes denatured thyroglobulin, denatured hemoglobin, and fibrinogen. It also rapidly hydrolyzes the ester substrates, benzoyltyrosine ethyl ester, benzoylphenylalanine ethyl ester, and acetyltyrosine ethyl ester. The pH optimum for thyroglobulin and benzoyltyrosine ethyl ester hydrolysis ...

Multi-competitive enzymatic reactions were performed to determine the selectivity properties of enzymes immobilised in polyacrylamide-alginate (pAAm-Alg) microcapsules. The transesterification of fatty acid ethyl esters of different chain lengths (C2–C14) with various alcohols catalysed by the enzyme lipase Mucor Miehei was chosen as a test system. While the free enzyme exhibited higher selecti...

The title compound, C(14)H(10)Cl(4)O(4)S, is a 2,2,2-trichloro-ethyl-protected precursor of 4'-chloro-biphenyl-3-yl sulfate, a sulfuric acid ester of 4'-chloro-biphenyl-3-ol. The C(aromatic)-O and O-S bond lengths of the C(aromatic)-O-S unit are comparable to those in structurally analogous biphenyl-4-yl 2,2,2-trichloro-ethyl sulfates with no electro-negative chlorine substituent in the benzene...

Although lipids are essential nutrients in the mammalian diet, we have shown that fatty acids are injurious to epithelial cells of developing piglet intestine during luminal perfusion. Furthermore, the intestine of young animals sustains greater injury than that of older piglets. In an effort to understand the mechanism for this developmental injury, we investigated whether changes in the chemi...

2-(Trimethylsilyl)ethyl 2,2,2-trichloroacetimidate is readily synthesized from 2-trimethylsilylethanol in high yield. This imidate an effective reagent for the formation of 2-trimethylsilylethyl esters without need exogenous promoter or catalyst, as carboxylic acid substrate acidic enough to promote ester additive. A deuterium labeling study indicated that a ?-silyl carbocation intermediate inv...