Lipids heading toward lysosomes that carry a mutated ion channel are spared from destruction, according to Meidel et al. (page 1477). The accumulating undigested fat eventually dooms the cell. Cells get rid of excess fat, which comes from worn-out organelles or engulfed pathogens by, for instance, shuttling them in endosomes to degradative lysosomes. The two organelles are thought to fuse when ...