BACKGROUND The neural correlates of working memory (WM) impairment in schizophrenia remain a key puzzle in understanding the cognitive deficits and dysfunction of dorsolateral prefrontal cortex observed in this disorder. We sought to determine whether patients with schizophrenia exhibit an alteration in the inverted-U relationship between WM load and activation that we recently observed in heal...

in this study, the authors reported a case of woman with severe compulsion who became pregnant during the repetitive transcranial magnetic stimulation. we carried out repetitive transcranial magnetic stimulation and behavior therapy simultaneously after repeated medications' refraction. the patient received 20 sessions 1 hz repetitive transcranial magnetic stimulation in right dorsolateral...

CONTEXT Postmortem studies have found evidence of γ-aminobutyric acid (GABA) deficits in fast-spiking, parvalbumin-positive interneurons in the prefrontal cortex in schizophrenia. Magnetic resonance spectroscopy studies in unmedicated patients have reported glutamine or glutamate-glutamine (Glx) elevations in this region. Abnormalities in these transmitters are thought to play a role in cogniti...

Despite a growing body of neuroimaging data, little consensus has been reached regarding the neural correlates of temporal processing in humans. This paper presents a reanalysis of two previously published neuroimaging experiments, which used two different cognitive timing tasks and examined both sub- and supra-second intervals. By processing these data in an identical manner, this reanalysis a...

introduction: studies with single photon emission computed tomography (spect) have revealed inconsistent changes of regional cerebral blood flow (rcbf) in schizophrenia. some studies investigated the rcbf and its relationship with psychopathology, positive and negative symptoms in treated patients. however, there is a little information about the pattern of rcbf in recently untreated or never t...

The dorsolateral prefrontal and posterior parietal cortices are two interconnected brain areas that are coactivated in tasks involving functions such as spatial attention and working memory. The response properties of neurons in the two areas are in many respects indistinguishable, yet only prefrontal neurons are able to resist interference by distracting stimuli when subjects are required to r...

Research shows that consuming ratings influences purchase decisions in e-commerce and also has modest effects on belief news articles social media. We find the act of producing reduces media induces users to think more critically. propose this intervention as a method encourage realize that, unlike product rating setting, who submit their for typically lack firsthand knowledge events reported n...

Self-compassion is an important emotion regulation strategy predicting positive psychological health and fewer psychopathological problems, but little known about its structural neural basis. In the current study, we investigated neurostructural correlates of dispositional self-compassion components using voxel-based morphometry (VBM). We found that was inversely correlated with gray matter vol...

This paper reports evidence linking dorsolateral prefrontal cortex with one of the cognitive abilities that emerge between 7.5-12 months in the human infant. The task used was Piaget's Stage IV Object Permanence Test, known as AB (pronounced "A not B"). The AB task was administered (a) to human infants who were followed longitudinally and (b) to intact and operated adult rhesus monkeys with bil...

Background Tamoxifen is the most widely used drug for treating patients with estrogen receptor-sensitive breast cancer. There is evidence that breast cancer patients treated with tamoxifen exhibit cognitive dysfunction. However, the underlying neural mechanism remains unclear. The present study aimed to investigate the neural mechanisms underlying working memory deficits in combination with fun...