Glutathione S-transferases (GSTs; EC: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. Functional genetic polymorphisms in genes encoding GSTM1 (a member of GST class mu; OMIM: 138350), and GSTT1 (a member of GST class theta; OMIM: 600436) have been well defined. The functional null alleles of GSTM1 and GSTT1 represent deletions of GSTM1 and GS...

We study numerically the fully nonlinear gravitational collapse of a self-gravitating, minimallycoupled, massless scalar field in spherical symmetry. Our numerical code is based on double-null coordinates and on free evolution of the metric functions: The evolution equations are integrated numerically, whereas the constraint equations are only monitored. The numerical code is stable (unlike rec...

While the additive model is a popular nonparametric regression method, many of its theoretical properties are not well understood, especially when the back tting algorithm is used for computation of the the estimators. This article explores those properties when the additive model is tted by local polynomial regression. Su cient conditions guaranteeing the asymptotic existence of unique estimat...

Null hypotheses are simple, precise, and theoretically important. Conventional statistical analysis cannot support them; Bayesian analysis can. The challenge in a Bayesian analysis is to formulate a suitably vague alternative, because the vaguer the alternative is (the more it spreads out the unit mass of prior probability), the more the null is favored. A general solution is a sensitivity anal...

We analyze the radiative aspects of nonsymmetric gravity theory to show that, in contrast to General Relativity, its nonstationary solutions cannot simultaneously exhibit acceptable asymptotic behavior at both future and past null infinity: good behavior at future null infinity is only possible through the use of advanced potentials with concomitant unphysical behavior at past null infinity.

Multiple amino acid changes within herpes simplex virus type 1 (HSV-1) gB and gK cause extensive virus-induced cell fusion and the formation of multinucleated cells (syncytia). Early reports established that syncytial mutations in gK could not cause cell-to-cell fusion in the absence of gB. To investigate the interdependence of gB, gK, and UL20p in virus-induced cell fusion and virion de-envelo...