Lumbar spine and proximal femoral bone densities of Caucasian women, aged 35-45, were measured by dual photon densitometry model DPX. The measurement sites were assessed at the lumbar spine (vertebrae L2 to L4) and at the proximal femur (trochanter, femoral neck and Ward's triangle). After exclusion of women with climacteric symptoms, sterilized patients or those with menopausal concentrations ...

General information. All manipulations were performed using Schlenk techniques under an Ar atmosphere. All solvents were dried and purified by standard procedures. Spectroscopic grade dichloromethane was used for all optical measurements. NMR spectra were recorded on Bruker DPX-200, AV 300 or AV 500 MHz spectrometers. H and C chemical shifts are given versus SiMe4 and were determined by referen...

Memetic Algorithms have been proven to be successful to find the nearest optimum solution to hard combinatorial optimization problems. In this paper, Memetic algorithm is designed for Asymmetric Traveling salesman problem (ATSP). Memetic Algorithm is a combination of power of Genetic algorithm with the powerful local search technique to focus on the population of local optima. Because of perfor...

Future cancer immunotherapies will combine multiple treatments to improve immune responses to cancer through synergistic, multi-modal mechanisms. In a Phase I clinical trial, we found that the immune response to a peptide vaccine targeting survivin, DPX-Survivac, by ovarian cancer patients can be improved by combination therapy with metronomic cyclophosphamide (mCPA). Pre-clinical studies in mi...

The aim of the present study was to evaluate a model of body composition for assessing total body protein (TBP) mass using dual-energy X-ray absorptiometry (DXA), with either measured or assumed total body water (TBW); it was intended to provide a less complex or demanding alternative technique to, for example, the four-component model (4-CM). The following measurements were obtained in healthy...

We tested whether adenosine has differential effects on vascular endothelial growth factor (VEGF) expression under normoxic and hypoxic conditions, and whether A1 or A2 receptors (A1R; A2R) mediate these effects. Myocardial vascular smooth muscle cells (MVSMCs) from dog coronary artery were exposed to hypoxia (1% O2) or normoxia (20% O2) in the absence and presence of adenosine agonists or anta...