The objective of this paper was to review existing information regarding food effects on drug absorption within paediatric populations. Mechanisms that underpin food-drug interactions were examined to consider potential differences between adult and paediatric populations, to provide insights into how this may alter the pharmacokinetic profile in a child. Relevant literature was searched to ret...

Interaction is a familiar term to most biostatisticians. When the effect of one factor differs across levels of a second factor, interaction between the factors is present. Drug disposition refers to the processes of how a drug is absorbed, distributed, metabolized (broken down), and excreted [6]. Variations in drug disposition and/or effect may result from interactions with, for example, disea...

The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively. Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used her...

INTRODUCTION A drug interaction is a pharmacological response which cannot be explained by the action of a single drug but may be due to two or more drugs acting simultaneously but The effects of a drug may also be changed by the presence of food, drink or by some environmental chemical agent. The outcome of a drug interaction may be harmful if the interaction results in increased efficacy or t...

The interaction between warfarin and thyroid replacement is one of the most frequent alerts provided to pharmacists by computerized drug interaction systems, so it is important to assess any new information on this interaction. Historically, we have held that the interaction between warfarin and thyroid would rarely be clinically important, because the patient is usually taking thyroid first, a...

OBJECTIVE To review all currently published drug-drug interaction studies with the HIV-integrase inhibitor raltegravir. METHODS A PubMed search was conducted for all published reports up to August 1, 2009 as well as a review of updated European and US Prescriber's Information (EMEA and FDA) and abstracts from recent international scientific meetings. RESULTS A total of 14 drug-drug interact...

Many patients treated with imatinib, used in cancer treatment, are using several other drugs that could interact with imatinib. Our aim was to study all the drug-drug interactions (DDIs) observed in patients treated with imatinib.We performed 2 observational studies, between the 1st January 2012 and the 31st August 2015 in the Midi-Pyrénées area (South Western France), using the French health i...

immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. this variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. drug monitoring is widely practiced ...