Aqueous solubility is a critical factor for optimum drug delivery. In the present study, we investigated the potential of drugcyclodextrin complexation as an approach for improving the solubility and bioavailability of famotidine, an H2-receptor antagonist and acid reducing drug which has poor solubility and bioavailability. Solubility improvement of drug by βcyclodextrin was done by simple com...

Spherically agglomerated solid dispersions of carvedilol (CAR) were prepared with polyvinyl-pyrrolidone (PVP) using acetone, water and dichloromethane as solvent, non-solvent and bridging liquid, respectively. The prepared agglomerates were evaluated for its percentage yield, drug content, morphology, thermal behavior, micromeritic properties, aqueous solubility and in vitro drug release. Diffe...

Pharmaceutical field is widely focusing on solubility parameter models to select solvent or non-solvent that can enhance solvency of drug. Solubility Parameter very useful concept in understanding the mechanism and behavior with their applications pharmaceuticals open door research having focus theoretical considerations solubility. Hildebrand Hansen are frequently used identify solvents.

The oral route is the preferred option for drug administration but contains the inherent issue of drug absorption from the gastro-intestinal tract (GIT) in order to elicit systemic activity. A prerequisite for absorption is drug dissolution, which is dependent upon drug solubility in the variable milieu of GIT fluid, with poorly soluble drugs presenting a formulation and biopharmaceutical chall...

The most common stoichiometry of drug/cyclodextrin complexes is 1:1, i.e. one drug molecule forms a complex with one cyclodextrin molecule, and the most common method for stoichiometric determination during formulation studies is the phase-solubility method. However, in recent years it has becoming increasingly clear that solubilizing effects of cyclodextrins are frequently due to the formation...

The aim of this study was to design orally disintegrating tablets of Olanzapine and to complex Olanzapine with 2-hydroxypropyl-β- cyclodextrin with special emphasis on disintegration and dissolution studies. Phase solubility studies demonstrated the formation of 1:1 molar inclusion complex by kneading method. Tablets were prepared by using superdisintegrants namely, sodium starch glycolate, cro...

The aim of this study was to design orally disintegrating tablets of Olanzapine and to complex Olanzapine with 2-hydroxypropyl-β- cyclodextrin with special emphasis on disintegration and dissolution studies. Phase solubility studies demonstrated the formation of 1:1 molar inclusion complex by kneading method. Tablets were prepared by using superdisintegrants namely, sodium starch glycolate, cro...

Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility have low dissolution rates and hence suffer from oral bioavailability problems. The poor solubility and poor dissolution rate of poorly water soluble drugs in the aqueous gastro intestinal fluids ...

PURPOSE The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate. METHODS Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP) and Labrafil(®) M 2125 as carriers using the electrospray technique, and the e...

aceclofenac is a non-steroidal anti-inflammatory drug (nsaid) that exhibits analgesic, antipyretic and anti-inflammatory activities. it is practically insoluble in water. the effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. the enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...