A review on applicability of in silico methods for toxicity testing by calculation for regulatory purposes, their survey and background of QSAR (Quantitative Structure-Activity Relationships) analysis are presented.

Consensus Regarding new Drug Applications. " The Agency has revised this guidance based on comments it received on the proposed implementation. This approach, designed to facilitate the early stages of pharmaceutical development, is not and ICH consensus position although it is considered to be in general agreement with the ICH position on acute toxicity testing. This guidance was published in ...

The development of assays for plasma antiepileptic drug concentrations has led to the discovery of many pharmacokinetic interactions, some causing drug intoxication and others resulting in ineffective drug concentrations. In the 1970s, a number of epileptologists began to argue that single drug therapy was desirable in the treatment of epilepsy and this has become the accepted policy when initi...

General drug toxicity has long been a concern of physicians. Recently, there has been increasing concern about the psychological side effects of drugs. This paper reviews the literature on psychological side effects of those drugs which have been most studied in recent years. It also includes a section reviewing the literature on miscellaneous drugs associated with psychological symptoms. This ...

background the increasing use of herbal drugs and their easy availability have necessitated the use of mutagenicity tests to analyze their toxicity and safety. objectives the aim of this study was to determine the in vitro mutagenicity of artemisia draconculus l., a herbal drug, by performing single cell gel electrophoresis (scge). materials and methods in this study, we obtained a herbal drug ...

MOTIVATION Drug-induced toxicity related proteins (DITRPs) are proteins that mediate adverse drug reactions (ADRs) or toxicities through their binding to drugs or reactive metabolites. Collection of these proteins facilitates better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery. Drug-induced toxicity related protein database (DITOP) is such a...

abstract background and objective: iranian traditional medicine (itm) has a long history in the prevention and treatment of diseases. clinical uses, side effects, and toxic effects of many singular and compounds were known to scientists of itm and articular books on toxicology and detoxification of drugs has been written by scientists, but their measurement tools to evaluate chronic toxicity of...