Solution NMR spectroscopy represents a powerful tool for examining the structure and function of biological macromolecules. The advent of multidimensional (2D-4D) NMR, together with the widespread use of uniform isotopic labeling of proteins and RNA with the NMR-active isotopes, 15N and 13C, opened the door to detailed analyses of macromolecular structure, dynamics, and interactions of smaller ...

The degradation of organic micropollutants occurs via different reaction pathways. Compound specific isotope analysis is a valuable tool to identify such degradation pathways in different environmental systems. We propose a mechanism-based modeling approach that provides a quantitative framework to simultaneously evaluate concentration as well as bulk and position-specific multi-element isotope...

Organic compounds are produced in vast quantities for industrial and agricultural use, as well as for human and animal healthcare [1]. These chemicals and their metabolites are frequently detected at trace levels in fresh water environments where they undergo degradation via different reaction pathways. Compound specific stable isotope analysis (CSIA) is a valuable tool to identify such degrada...

Noninvasive imaging strategies will be critical for defining the temporal characteristics of angiogenesis and assessing efficacy of angiogenic therapies. The alphavbeta3 integrin is expressed in angiogenic vessels and represents a potential novel target for imaging myocardial angiogenesis. We demonstrated the localization of an indium-111-labeled ((111)In-labeled) alphavbeta3-targeted agent in ...

The organization of lipids within biological membranes is poorly understood. Some studies have suggested lipids group into microdomains within cells, but the evidence remains controversial due to non-native imaging techniques. A recently developed NanoSIMS technique indicated that sphingolipids group into microdomains within membranes of human fibroblast cells. We extended this NanoSIMS approac...

The Alpha Magnetic Spectrometer (AMS), to be installed on the International Space Station (ISS) in 2008, is a cosmic ray detector with several subsystems, one of which is a proximity focusing Ring Imaging Čerenkov (RICH) detector. This detector will be equipped with a dual radiator (aerogel+NaF), a lateral conical mirror and a detection plane made of 680 photomultipliers and light guides, enabl...

Common dispersive-type spectroscopic instruments include prism-type and grating-type, usually using a single dispersive element. The continuous imaging band is always limited by the dispersion angle. When it necessary to image two wavebands with an ultra-spectral resolution that are far apart, difficult due large diffraction To broaden spectral coverage of spectrometer, in this paper, we propos...