BACKGROUND GH pulses are putatively initiated by hypothalamic GH-releasing hormone (GHRH), amplified by GH-releasing peptide (GHRP), and inhibited by somatostatin (SS). OBJECTIVE To ascertain how secretagogues control the waveform (time evolution of release rates) as well as the mass of secretory bursts. DESIGN We quantified the shape of GH secretory bursts evoked by continuous combined i.v...

Microglia are the resident macrophages of the central nervous system (CNS). In physiological conditions, resting microglia maintain tissue integrity by scanning the entire CNS parenchyma through stochastic and complex movements of their long processes to identify minor tissue alterations. In pathological conditions, over-activated microglia contribute to neuronal damage by releasing harmful sub...

BACKGROUND The aim of this study was to evaluate bone mineral density (BMD) at baseline and at 18 and 36 months of use of etonogestrel (ENG)-and levonorgestrel (LNG)-releasing contraceptive implants. This is a continuation of a previous study in which BMD was evaluated at baseline and at 18 months of use. METHODS A total of 111 women, 19-43 years of age, were randomly allocated to use one of ...

The purpose of the present study was to determine the mechanism(s) involved in carbon monoxide-releasing molecule-2, carbon monoxide-releasing molecule-2-induced cardioprotection. We used the transition metal carbonyl compound carbon monoxide-releasing molecule-2 that can act as carbon monoxide donor in cardiac ischaemia-reperfusion injury model using isolated rat heart preparation. Langendorff...

this paper is an investigation of $l$-dual frames with respect to a function-valued inner product, the so called $l$-bracket product on $l^{2}(g)$, where g is a locally compact abelian group with a uniform lattice $l$. we show that several well known theorems for dual frames and dual riesz bases in a hilbert space remain valid for $l$-dual frames and $l$-dual riesz bases in $l^{2}(g)$.

Leptin and corticotrophin-releasing factor increase sympathetic nervous activity to interscapular brown adipose tissue, kidneys, and adrenal glands. Leptin is known to increase hypothalamic corticotrophin-releasing factor. In this study, we tested the hypothesis that leptin-dependent increases in sympathetic nervous activity are mediated through increases in central nervous system corticotrophi...