The “one drug – one target – one disease” paradigm in drug discovery has been reconsidered during the last decade. This paradigm change was mainly caused by high attrition rates in drug approvals due to toxicity and lack of efficacy. Computational techniques play an important role in prediction and recognition of novel targets for approved drugs. We will discuss two machine learning approaches ...

A selection of these reports is available in PostScript form at the Faculty's anonymous ftp-Abstract In this paper we propose a method for linear programming with the property that, starting from an initial non{central point, it generates iterates that simultaneously get closer to optimality and closer to centrality. The iterates follow so{called targets, that are updated with long steps. Newto...

In this study, we report BF066, a novel adenine derivative, inhibits platelet activation and thrombosis via the adenosine receptor (A(2A)) activation and phosphodiesterase (PDE) inhibition. BF066 inhibits platelet aggregation and ATP releasing induced by multiple platelet agonists in a dose-dependent manner. The inhibition of BF066 on ADP-induced aggregation is potentiated by adenosine and can ...

Professional visual searches (e.g., baggage screenings, military searches, radiological examinations) are often conducted in high-pressure environments and require focus on multiple visual targets. Yet laboratory studies of visual search tend to be conducted in emotionally neutral settings with only one possible target per display. In the experiment reported here, we looked to better emulate hi...

When engaged in a visual search for two targets, participants are slower and less accurate in their responses, relative to their performance when searching for singular targets. Previous work on this "dual-target cost" has primarily focused on the breakdown of attentional guidance when looking for two items. Here, we investigated how object identification processes are affected by dual-target s...

A simple through-the-wall radar system for moving target localization is proposed. This scheme is based on trilateration and range estimation from three independent dual-frequency CW radar units. The dual-frequency technique uses phase comparison of the transmitted and received CW signals to provide an estimate of the range-to-motion. The difference in frequency of the two CW carriers determine...

Over the last three decades, phage display technology has been used for the display of target-specific biomarkers, peptides, antibodies, etc. Phage display-based assays are mostly limited to the phage ELISA, which is notorious for its high background signal and laborious methodology. These problems have been recently overcome by designing a dual-display phage with two different end functionalit...

Monoamine oxidase B (MAO-B) inhibitory potential of adenosine A(2A) receptor (AA(2A)R) antagonists has raised the possibility of designing dual-target-directed drugs that may provide enhanced symptomatic relief and that may also slow the progression of Parkinson's disease (PD) by protecting against further neurodegeneration. To explain the dual inhibition of MAO-B and AA(2A)R at the molecular l...

Inhibitors of the renin-angiotensin system (RAS) form a cornerstone in the treatment of kidney disease. These drugs lower blood pressure and albuminuria, and afford renal protection. Dual therapy with an angiotensin-converting enzyme inhibitor and angiotensin receptor blocker have been shown to be more effective in reducing blood pressure and albuminuria than the single use of these agents. It ...

This paper develops a log-likelihood ratio test statistic for resolved target detection in dual-band imagery because the previous work indicates that most of the processing gains come from processing just two bands. Simple, closed-form equations for the closed-form probabilities of false alarm and detection are given. A computer simulation validates the theory. A constant false alarm rate versi...