Patent ductus arteriosus (PDA) is a congenital heart disease defined as the arterial connection between the pulmonary artery and the aorta. The ductus arteriosus is an essential structure that shunts blood away from the lungs during fetal life, and only becomes abnormal if it remains patent more than three months after birth in term infants. Spontaneous delayed closure of the ductus arteriosus ...

Nonselective cyclooxygenase (COX) inhibitors are potent tocolytic agents but have adverse effects on the fetal ductus arteriosus. We hypothesized that COX-2 inhibitors may not affect the ductus if the predominant COX isoform is COX-1. To examine this hypothesis, we used ductus arteriosus obtained from late-gestation fetal lambs. In contrast to our hypothesis, fetal lamb ductus arteriosus expres...

We have modified and applied to selected outpatients the transvenous approach to correction of patent ductus arteriosus (PDA) with the Rashkind PDA Occluder. Modifications included establishing the diagnosis and PDA anatomy before catheterization with echocardiography. The sedation/anesthetic regimen was altered to meet the needs with respect to transcatheter PDA closure rather than diagnostic ...

Isolated subclavian artery is a rare anomaly where the artery, instead of originating from aorta, connected to ipsilateral pulmonary via ductus arteriosus. Presentation varies asymptomatic vertebrobasilar insufficiency and claudication arm. About 100 odd cases were reported in literature. Some them underwent definitive surgical repair, ie, reimplantation others percutaneous closure patent arter...

The management of patent ductus arteriosus in the preterm infant is one of the areas of clinical care that is subjected to great practice variation. This is sadly one of the consequences of widespread adoption of closure of the patent ductus arteriosus by pharmacological or surgical means without subjecting the treatment approaches to rigorous randomized control trials. The diverse approaches t...

BACKGROUND Ibuprofen is used for treatment and prevention of patent ductus arteriosus in low-birthweight infants. Its effects on regional circulations differ from those of indometacin. Because prophylactic indometacin reduces the frequency of severe intraventricular haemorrhage and patent ductus arteriosus, we aimed to study the efficacy of early ibuprofen in reducing these outcomes in a double...

W HEN there is a right-sided aortic arch, persistence of a left-sided ductus arteriosus can readily be demonstrated by angiocardiography. This is important because in some types of eyanotic congenital heart disease, such as in the tetralogy of Fallot, anl artificial aortico-pulmonary (Blalock-Taussig' or Pott S2 shunt) is often created in order to alleviate the distress produced by anoxia. Two ...

Purpose: To review the results of ligation of patent ductus arteriosus in premature babies in an intensive care unit. Method: Retrospective review of premature babies who underwent ligation of patent ductus arteriosus in the intensive care unit, Grantham Hospital, during the period from January, 1999 to December, 2002. Results are compared with those who underwent ligation of patent ductus arte...

T he ductus arteriosus allows deoxygenated blood from the right ventricle through the descending aorta and to the placenta in the fetal period. Functional and anatomical closure is complete by several weeks after birth. Patients with ductus-dependent physiology generally have advanced congenital malformations and require surgical intervention early in life. However, some patients will present a...