AIMS To explore the association between duodenal adenoma and carcinoma in patients with familial adenomatous polyposis (FAP). METHODS A multicentre survey of 1262 patients with FAP yielded 47 cases of duodenal cancer. The association between adenoma and cancer was assessed in these cases. RESULTS Adenomatous tissue was found within duodenal cancer in 29 of 44 (66%) patients with FAP and in ...

Duodenal ulceration is a chronic disease the causes of which remain unknown. Current medical treatment interrupts the natural history and accelerates ulcer healing. It does not cure ulcers. All duodenal ulcers are generally considered together even though pathophysiological mechanisms differ from patient to patient. It should not be surprising that some duodenal ulcer patients respond relativel...

(BGHs) are uncommon duodenal lesions, and account for approximately 5% of all duodenal masses (1). BGHs contain cysts on rare occasions, and only a very small number of cases of cystic BGH with accompanying computed tomography (CT) or magnetic resonance imaging (MRI) documentation have been reported (2-4). Imaging diagnosis of BGHs is usually a challenge, due to their nonspecific appearance. Th...

Gastric mucosal phospholipids, and in particular those of the surface layer, play an important part in mucosal barrier function. This study examined whether the phospholipid composition of the full thickness gastric mucosa is changed in peptic ulcer disease and gastritis. The phospholipid composition of gastric mucosa from endoscopic biopsy specimens in 28 subjects (eight healthy controls, 12 p...

BACKGROUND There is a high prevalence of gastro-duodenal disease in sub-Saharan Africa. Peptic ulcer disease in dyspeptic patients, 24.5%, was comparable to prevalence of gastro-duodenal disease among symptomatic individuals in developed countries (12 - 25%). Limited data exists regarding its associated risk factors despite accumulating evidence indicating that gastroduodenal disease is common ...

BACKGROUND AND AIMS The existence of gastric metaplasia (GM) of the duodenal mucosa has been considered to be highly related to the recurrence of duodenal ulcers (DU). The aims of this study are to evaluate the usefulness of methylene blue staining in the detection of GM, and to clarify the relationship between GM and the deformity of the duodenal bulb. METHODS Fifteen patients with healed DU...

Patients with classical familial adenomatous polyposis (FAP) present with hundreds of colorectal adenomas requiring (sub)total colectomy at around age 20 years, and frequently duodenal adenomas. Duodenal polyposis is a progressive disease. The burden of duodenal adenomas evolves more slowly as compared to colorectal adenomas, but increases with age to the highest stage of duodenal polyposis, st...

Dong, Hui, Anders Smith, Marjan Hovaida, and Jimmy Y. Chow. Role of Ca -activated K channels in duodenal mucosal ion transport and bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 291: G1120–G1128, 2006. First published June 8, 2006; doi:10.1152/ajpgi.00566.2005.—Stimulation of muscarinic receptors in the duodenal mucosa raises cytosolic free Ca concentration ([Ca ]cyt), thereby r...

BACKGROUND Helicobacter-pylori-related duodenal ulcer (DU) is an important cause of dyspepsia. AIM To determine the relationship between the pattern of H. pylori infection and the epidemiology of duodenal ulcer in a single population. DESIGN Prospective two-part study of (i) patients with DU referred for endoscopy because of dyspepsia, and (ii) the incidence of H. pylori infection in the ge...

Duodenal stent placement has been developed as an alternative to surgical gastrojejunostomy [1]. Compared with uncovered metallic stents, duodenal fully covered metallic stents offer advantages, such as the prevention of tumor ingrowth, and thus lower occlusion rates [2]. However, duodenal fully covered metallic stents also have several disadvantages, such as stent migration [3]. Acute pancreat...