We describe a case in which segmental resection of the third portion of the duodenum was performed for a gastrointestinal stromal tumor (GIST). A 31-year-old woman was found to have a 3.5 cm hypovascular tumor at the posterior inferior aspect of the pancreatic head. Preoperative duodenal biopsy revealed that the tumor was positive for c-kit and vimentin, and was diagnosed as a duodenal GIST. Se...

Objectives. Zollinger-Ellison Syndrome (ZES) results in hypersecretion of gastric acid (via gastrinoma) leading to peptic ulcers, diarrhea, and abdominal pain. We describe the novel discovery of hypertrophic, heterotopic gastric mucosa in the proximal duodenal bulb in patients with ZES, which we hypothesize results in an increased incidence of postbulbar ulcers in patients with ZES (a mechanism...

The upper digestive tract is routinely scoped for several causes of malabsorption, and the number of duodenal biopsy specimens has increased notably in the last 10 years. Gluten-sensitive enteropathy (GSE) is an autoimmune disease, which shows an increasing prevalence worldwide and requires a joint clinico-pathological approach. The classical histopathology of GSE with partial or total villous ...

Gastrointestinal stromal tumors (GISTs) are low-grade malignant mesenchymal tumors of GI tract and are believed to originate from malignant transformation of the interstitial cells of Cajal from their precursors [1]. Duodenal GISTs are usually exophytic and appear as submucosal swellings [2]; however, in the absence of specifi c mucosal changes or anatomical variations of the duodenal lumen, it...

BACKGROUND Treatment of Helicobacter pylori infection prevents duodenal ulcer relapse. It has not been established if treatment of the infection heals duodenal ulcer. AIM To test the hypothesis that treatment of the infection was associated with healing of duodenal ulcer. METHODS A randomised, double blind placebo controlled trial was performed to study the efficacy of an antibiotic only re...

Gastric mucosal phospholipids, and in particular those of the surface layer, play an important part in mucosal barrier function. This study examined whether the phospholipid composition of the full thickness gastric mucosa is changed in peptic ulcer disease and gastritis. The phospholipid composition of gastric mucosa from endoscopic biopsy specimens in 28 subjects (eight healthy controls, 12 p...

Clinical features of giardiasis vary greatly between individuals and may range from asymptomatic infection to severe malab− sorption syndrome. Whereas individuals with various forms of hypogammaglobu− linemia may show more severe disease and damage to the intestinal villi, AIDS patients do not appear to be at increased risk of severe giardiasis [1]. We present a case of duodenal giardiasis in a...

AIM To assess the clinical characteristics of Helicobacter pylori (H pylori) negative duodenal ulcer. METHODS Patients with an endoscopic diagnosis of duodenal ulcer between 1996 and 2002 were included in the present study. Patients were considered to be negative for H pylori, if both histological examination and rapid urease test of biopsy specimens were negative. A comparison was made betwe...

BACKGROUND Dietary hypersensitivity and inflammatory bowel disease (IBD) are important causes of chronic vomiting and diarrhea in cats. IL-23 has been recently found to be a key factor in the immunopathogenesis of IBD in humans but the involvement in IBD has not been investigated in cats. HYPOTHESIS/OBJECTIVES Expression of genes encoding Il-12p35 and p40, IL-23p19, and IFN-γ may be up-regula...