Oxidative stress participates in doxorubicin (Dx)-induced cardiotoxicity. The metal complex MnDPDP and its metabolite MnPLED possess SOD-mimetic activity, DPDP and PLED have, in addition, high affinity for iron. Mice were injected intravenously with MnDPDP, DPDP, or dexrazoxane (ICRF-187). Thirty minutes later, mice were killed, the left atria were hung in organ baths and electrically stimulate...

The immune response of mice to the alpha-l-6 epitope of dextran (Dx) B512 was found to be under genetic control. The congenic mouse strains A, A.CA, A.SW, A.TH, and A.TL exhibited a specific defect in their response to alpha-l-6. Also strain CBA/N was unresponsive to alpha-1-6, but the mechanism of unresponsiveness was found to be different. Unresponsiveness to alpha-l-6 in congenic A strains w...

1 1 , , 0, , r s p u u h x u dx g x u dx x u x + + −∆ = + ∈ Ω = ∈ ∂Ω () 1, 0 p W Ω () () () 1 1 , 0. r s p u x h x u dx g x u dx in u on + +  −∆ = + Ω   = ∂Ω   () E () () 1 1 / r p s Np N p N p < < − < < − + − () () () 0 0 r h L L C ∞ ∈ Ω Ω Ω   0 1 1 1, r r p * + + = ()() 0. 1 Np r Np r N p = − + − () () 0 s g L L ∞ ∈ Ω Ω  0 1 1 1, s s p * + + = ()() 0 ,. 1 Np Np s p Np s N p N p *   ...

KLK1 (tissue kallikrein 1) is a member of the tissue kallikrein family of serine proteases and is the primary kinin-generating enzyme in human airways. DX-2300 is a fully human antibody that inhibits KLK1 via a competitive inhibition mechanism (Ki=0.13 nM). No binding of DX-2300 to KLK1 was observed in a surface-plasmon-resonance biosensor assay when KLK1 was complexed to known active-site inhi...

Muscle weight, protein content and contractile performance (tetanic tension, fatigue and recovery) of extensor digitorum longus and soleus were investigated in rat following systemic administration of Dexamethasone (DX), 5 mg/kg/day for ten days. These animals showed marked reduction in food intake during the course of DX treatment. As a control, a group of food restricted (FR) rats receiving e...

We have studied the effect of DX-88, a selective recombinant inhibitor of human plasma kallikrein, in transient or permanent focal brain ischemia (with or without reperfusion, respectively) induced in C57BL/6 mice. Twenty-four hours after transient ischemia, DX-88 administered at the beginning of ischemia (pre) induced a dose-dependent reduction of ischemic volume that, at the dose of 30 microg...

Many diseases affecting the posterior segment of eye require repeated intravitreal injections with corticosteroids in chronic treatments. The periocular administration is a less invasive route attracting considerable attention for long-term therapies. In present work, dexamethasone-loaded poly(lactic-co-glycolic) acid (PLGA) microspheres (Dx-MS) were prepared using oil-in-water (O/W) emulsion s...

The Smoluchowski equation is a nonlinear integro-differential equation describing the evolution of the concentration μt(dx) of particles of mass in (x, x+ dx) in an infinite particle system where coalescence occurs. We introduce a class of algorithms, which allow, under some conditions, to simulate exactly a stochastic process (Xt)t≥0, whose time marginals are given by (xμt(dx))t≥0.

and Applied Analysis 3 for any fixed T > 0. Then v,H can be extended beyond T > 0 if one of the following conditions is satisfied: 1 u ∈ C ( 0, T ;Ln/3 ) , 1.11 2 u ∈ L 0, T ;L with 2 p n q 3, n 3 < q ≤ n, 1.12 3 ∇u ∈ C ( 0, T ;Ln/4 ) , 1.13 4 ∇u ∈ L 0, T ;L with 2 p n q 4 with n 4 < q ≤ n 2 . 1.14 Remark 1.5. If we delete the harmless lower order terms ∂tu − Δu and ∂tB − ΔB in 1.1 and 1.2 , th...