The single-dose pharmacokinetics of intravenously administered cefoperazone (2.0 g) and sulbactam (1.0 g) were studied in normal subjects and in patients with various degrees of renal failure. In an open, parallel experimental design, six normal subjects (creatinine clearance, greater than 90 ml/min), two patients with mild renal failure (creatinine clearance, 31 to 60 ml/min), eight patients w...

M e t h o d s Design: Randomized controlled trial. Allocation: Concealed.* Blinding: Blinded (outcome assessors).* Follow-up period: Up to 90 days. Setting: 21 intensive care units (ICUs) in university or community hospitals in France. Patients: 360 patients (mean age 65 y, 73% men) who had ARF, the multiple-organ dysfunction syndrome, and need for renalreplacement therapy. Exclusion criteria i...

We compared oral fluid testing to urine testing in subjects who were administered single doses of marijuana by smoked and oral routes. Oral fluid specimens were collected with the Intercept DOA Oral Specimen Collection Device, screened for THC with the Cannabinoids Intercept MICRO-PLATE Enzyme Immunoassay (EIA) utilizing a 1.0-ng/mL cutoff concentration, and confirmed for THC by gas chromatogra...

Changes in drug metabolism throughout the day have been extensively examined. Antipyrine is a widely used as model drug for cytochrome P450 (CYP450) dependent metabolism. The study performed on man and laboratory animals indicated, that content of protein, carbohydrates and lipids in diet can modify the activity of enzymes CYP450 complex. The aim of this study was to determine the diurnal chang...

This study examined the effects of beetroot juice (BTJ) on recovery between two repeated-sprint tests. In an independent groups design, 20 male, team-sports players were randomized to receive either BTJ or a placebo (PLA) (2 × 250 mL) for 3 days after an initial repeated sprint test (20 × 30 m; RST1) and after a second repeated sprint test (RST2), performed 72 h later. Maximal isometric volunta...

Human infection with fish parasites can result from the ingestion of incompletely cooked or raw fish, giving origin to parasitic diseases such as anisakiasis, caused by parasites of the Anisakidae family. The present study assessed the in vitro larvicidal effect of two monoterpene compounds, geraniol and citronellal, against Contracaecum sp (Nematoda: Anisakidae). Four hundred live larvae of Co...

Onpi-to, an herbal medicine composed of five crude drugs (Rhei Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber), was administered orally to rats. Onpi-to includes 1.240% of total potential rhein derived from sennoside A, sennoside B, rhein 8-O-glucopyranoside and rhein. Plasma, urinary and biliary levels of rhein were determined by an HPLC-UV method. The plasma ...

AIM To investigate the expression level and effects of leptin in human hepatocellular carcinoma cells in vitro and to explore the correlation between them. METHODS Human hepatocellular carcinoma cell line HepG2 was cultured in vitro, and (the expression level) mRNA of leptin and leptin receptors in HepG2 were assessed using reverse transcription polymerase chain reaction (RT-PCR). Effects of ...

An interesting property for many probiotic strains is to exhibit antimicrobial activity against pathogenic microorganisms. Therefore, the of potentially strain Lactobacillus acidophilus L12 Escherichia coli, Staphylococcus aureus and Salmonella sp. was examined in vitro through co-culturing with each 72 h. When cultured individually, all reached a final population always exceeding 10 12 cfu/mL....