This paper studies the state-dependent effects of shocks to distortionary tax rates in a dynamic stochastic general equilibrium (DSGE) model augmented with a number of real and nominal frictions. The tax output multiplier is defined as the change in output for a one dollar change in tax revenue caused by a shock to distortionary tax rates on consumption, labor income, or capital income. We find...

The interest in integrase-defective lentiviral vectors (IDLVs) stems from their potential advantage of large cloning capacity and broad cell tropism while avoiding the possibility of insertional mutagenesis. Here, we directly compared the transducing potential of IDLVs based on the equine infectious anemia virus (EIAV) to the more commonly described HIV-1 IDLVs. IDLVs were constructed by introd...

A long-term sodium nitrite infusion is intended for the treatment of vascular disorders. Phase I data demonstrated a significant nonlinear dose-exposure-toxicity relationship within the therapeutic dosage range. This study aims to develop a quantitative systems pharmacology model characterizing nitric oxide (NO) metabolome and methemoglobin after sodium nitrite infusion. Nitrite, nitrate, and m...

Immigration is often seen as an instrument of adaptation for aging countries. In this paper, we evaluate, using a dynamic general equilibrium model, the contribution of migration policy in reducing the tax burden associated with the aging population in France. Four alternative scenarios, compared to a baseline scenario based on official projections, are simulated with the aim to quantify the im...

The transport systems are dependent on the fossil fuels especially liquid fuels and these fuels are depleting at much faster rate than production. The consumption of fossil fuels is very unstable and directly affects the economy of our country as we are importing it from other nations so this factor has urged us to find other alternatives to prolong the usage of petroleum. Thus, by using bio-fu...

1878-3317/$ e see front matter Copyright 2012, Ta doi:10.1016/j.jecm.2012.01.004 Alcohol-related problems cause a tremendous social and public health burden worldwide. Alcohol dependence (AD) is a common, chronic and relapsing psychiatric disorder, with prevalence varying among different ethnic populations, and determined by a combination of genetic and environmental factors. The heritability o...

Immunity to one of the four dengue virus (DV) serotypes can increase disease severity in humans upon subsequent infection with another DV serotype. Serotype cross-reactive antibodies facilitate DV infection of myeloid cells in vitro by promoting virus entry via Fcgamma receptors (FcgammaR), a process known as antibody-dependent enhancement (ADE). However, despite decades of investigation, no in...

â â â â  libya experienced a substantial increase in oil revenue as a result of increased oil prices during the period of the late 1970s and early 1980s, and again after 2000. recent increases in oil production and the price of oil, and their positive and negative macroeconomic impacts upon key macroeconomic variables, are of considerable contemporary importance to an oil dependent economy such...

A geothermal heat exchanger system is mathematically quantified, and simulated and modeled to understand heat transfixion and strata deformation caused by groundwater exploitation via groundwater heat pump systems. This is done to determine the requirements and parameters governing the development of shallow geothermal energy in an efficient and safe manner. The model takes into account the gro...

This paper presents a political economy model of inflation as a result of social conflict. Agents are heterogeneous in terms of income. Agents’ income levels determine their ability to hedge against the effects of inflation. The interaction of heterogeneous cash holdings and preferences over fiscal policy leads to conflict over how to finance government expenditure. The model makes a number of ...