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Alzheimers disease is the most common form of dementia in adults aged 65 or older. While many neuro-imaging based biomarkers have been proposed over the years for detection of AD, these have mostly been hand-crafted and utilized domain-specific clinical knowledge. In this project, we are interested in automatically discovering such biomarkers (hidden cues) by using deep learning methods to clas...

Positron Emission Tomography (PET) scan images are one of the bio medical imaging techniques similar to that of MRI scan images but PET scan images are helpful in finding the development of tumors. The PET scan images requires expertise in the segmentation where clustering plays an important role in the automation process. The segmentation of such images is manual to automate the process cluste...

Prediction of Alzheimers disease (AD) progression based on baseline measures allows us to understand disease progression and has implications in decisions concerning treatment strategy. To this end we combine a predictive multi-task machine learning method1 with novel MR-based multivariate morphometric surface map of the hippocampus2 to predict future cognitive scores of patients. Previous work...

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Background—To determine if the APOE e4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTL) during successful memory encoding in young adults. Methods—Twenty-four healthy young adults, twelve carriers and twelve non-carriers of the APOE e4 allele, were scanned in a subsequent memory paradigm, using event-related functional magnetic resonance imagi...

cognize this dilemma might encourage them to develop functional teams. Individual neurologists and geriatricians could continue to diagnose routine neurological problems referred to them. In addition, they could subspecialize so that each might have a specific input in a multidisciplinary team which focused, for example, on the diagnosis and continuing care of the big three: stroke, the epileps...

Alzheimer's disease (AD) is the most common neurodegenerative disorder. Currently available therapies are symptomatic but do not alter underlying disease progression. Immunotherapeutic approaches such as anti Aβ peptide active vaccination trials have had limited success to date. Intravenous immunoblobulin (IVIg) is widely used in immune-mediated neurological disorders such myasthenia gravis and...

We previously have found biofilms in the hippocampi of Alzheimer’s disease (AD) post mortem brain specimens. We had seen them in an extracellular location and noted them to be present in the areas of pathological plaque formation. Other investigators have found the presence of spirochetes (Lyme and dental) in affected (AD) brains, and these have been correlated with Treponema pallidum. In a rec...