OBJECTIVES Extreme hyperbilirubinemia (plasma bilirubin ≥ 24.5 mg/dL) is an important risk factor for severe bilirubin encephalopathy. Several risk factors for hyperbilirubinemia are known, but in a large number of patients, a causal factor is never established. UGT1A1 is the rate-limiting enzyme in bilirubin's metabolism. The genotype of Gilbert syndrome, the UGT1A1*28 allele, causes markedly ...

Background: Neonatal Hyperbilirubinemia is a common problem encountered in neonates and often requires admission and treatment. Aims & Objectives: To determine the incidence, etiology and risk factors associated with neonatal hyperbilirubinemia in a tertiary care hospital. Materials and Methods: A retrospective study was conducted on data obtained on live births for 2012 and 2013.All treated ca...

We report a case of hemolytic anemia as an initial manifestation of hepatitis A virus infection. On admission, the patient had anemia, reticulocytosis, and direct and indirect hyperbilirubinemia. On subsequent examination, he had both glucose-6-phosphate dehydrogenase deficiency (G6PD) and autoimmune antibodies.

OBJECTIVE To investigate biological and health services predictors of extreme neonatal hyperbilirubinemia in a health maintenance organization. DESIGN Nested case-control study. SETTING Eleven Northern California Kaiser Permanente hospitals. SUBJECTS The cohort consisted of 51,387 newborns born at 36 weeks or later weighing 2000 g or more. Cases were newborns with peak total serum bilirub...

Although neonatal jaundice is common, acute bilirubin encephalopathy and kernicterus (i.e., chronic bilirubin encephalopathy) are rare. Universal screening for neonatal hyperbilirubinemia is controversial. The American Academy of Pediatrics recommends universal screening with bilirubin levels or targeted screening based on risk factors. However, the U.S. Preventive Services Task Force and the A...

Background: Neonates with urinary tract infection (UTI) are susceptible to higher rates of morbidity and mortality, specifically when presented hyperbilirubinemia. Screening for UTIs in jaundiced neonates is a cost-effective strategy. The aims this study were investigate the pattern UTI (prevalence, etiology, antimicrobial agents) admitted NICU unexplained indirect hyperbilirubinemia, as well i...

Background: Jaundice is frequently associated with extrahepatic systemic infections. The important causes include increased bilirubin levels due to hemolysis, hepatic dysfunction, reduced excretion and cholestasis. Sepsis induced cholestasis has a unique pathophysiologic basis. Although common in gram negative sepsis among neonates, the clinical features of sepsis induced cholestasis are not wi...

OBJECTIVES To develop and validate a predischarge risk stratification model by using transcutaneous bilirubin (TcB) values and clinical factors to predict significant postdischarge hyperbilirubinemia in healthy term and late preterm Chinese neonates. METHODS In a prospective cohort study, 8215 healthy term and late preterm neonates in 8 hospitals in China underwent TcB measurement at <168 hou...

introduction:  inadequate intake of breast milk in the first days of life leads to weight loss in neonates. jaundice is also more prominent in these infants. in this cross-sectional study, we tried to evaluate the extent of weight loss in term breastfed infants who were hospitalized for idiopathic hyperbilirubinemia. methods: this prospective study involved 1072 infants >48 hours old, who were ...