BACKGROUND/AIMS Hepatocellular carcinoma (HCC) also known as malignant hepatoma is a most common liver cancer. Doxorubicin (Doxo) is an anti-cancer drug having activity against a wide spectrum of cancer types. Clinical Utility of doxo has been limited due to its poor bioavailability and toxicity to heart and spleen. Furthermore, cancer chemotherapeutics have limited oral absorption. Transferrin...

Abstract. Permanasari I, Sulistyaningsih E, Kurniasih B, Indradewa D. 2023. Morphophysiological and yield traits of soybean varieties tolerant intercropping with maize. Biodiversitas 24: 3872-3880. Not all grow optimally when intercropped Previously, we identified seven (i.e., "Demas 1", Dena "Dena 2", "Derap "Devon "Wilis") two "Dega 1" "Mahameru") as intolerant based on selection indices yiel...

Anthocyanins are known to possess potent anticarcinogenic properties against several cancers thus demonstrating potential for cancer prevention. Black currant (Ribes nigrum L., Grossulariaceae) fruits have a high anthocyanin content. This "superfruit" is known to possess various pharmacological effects including alleviation of chronic oxidative stress and inflammation. In contrast to a large vo...

BACKGROUND The present study was conducted to evaluate the tumor suppressive effects of bone marrow derived mesenchymal stem cells (MSCs) in an experimental hepatocellular carcinoma (HCC) model in rats and to investigate the possible role of Wnt signaling in hepato-carcinogenesis. METHODS Ninety rats were included in the study and were divided equally into: Control group, rats which received ...

An initiation/promotion bioassay for chemical carcinogens and tumor promoters has been developed in rat liver using presumed preneoplastic lesions, foci of gamma-glutamyltranspeptidase (GGTase)-positive hepatocytes, as the endpoint. To evaluate the tumor-promoting activity of phenobarbital, rats were administered diethylnitrosamine (DENA), 2.0 mmole/kg, followed by 500 ppm phenobarbital in thei...

BACKGROUND AND AIMS Doxorubicin is a potent anticancer drug and a major limiting factor that hinders therapeutic use as its high levels of systemic circulation often associated with various off-target effects, particularly cardiotoxicity. The present study focuses on evaluation of the efficacy of doxorubicin when it is loaded into the protein nanoparticles and delivered intravenously in rats be...

Following the Russian invasion of Ukraine this February, a global community volunteers has endeavored to help preserve Ukraine’s online cultural heritage. While comprises over 1300 volunteers, many them work as librarians or in preservation, including two leaders group, Quinn Dombrowski and Anna Kijas. Kijas, along with Sebastian Majstorovic, have been instrumental coordinating experts across t...

dena biosphere reserve located in iran and is a 550 biosphere reserve in the worlds. this research was investigated in the two protected and non-protected areas, in a dena biosphere reserve, kohkeloye va boyrahmad province, and central zagros forest, southwest of iran. inventory methods designed by systemetic-randomaiz method by use the rectangular plots that were 15×30 meters in the 100×100 m ...