Recent evidence indicates that the commitment to degrade cellular proteins by the ubiquitin proteolytic pathway is dependent on the covalent attachment of multiubiquitin chains to the target protein [Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K. & Varshavsky, A. (1989) Science 243, 1576-1583]. We have isolated a 20-kDa ubiquitin carrier protein [E2(20 kDa)] fro...

608. Can Rapid Molecular Diagnostics Assist in the Choice of b-Lactam Antibiotics? An Analysis of Data from PRIMERS-II of the Antibiotic Resistance Leadership Group (ARLG) Andrea M. Hujer, BS; Scott Evans, PhD; Hongyu Jiang, PhD; Kristine M. Hujer, BS; Thomas Hall, PhD; Christine Marzan, PhD; Michael Jacobs, MD, PhD; Ranga Sampath, PhD; David J. Ecker, PhD; T. Nicholas Domitrovic, BA; Claudia M...

A patellar tendon tear needs a force equivalent to 15 times the weight to overcome the strength of the tendon. It usually occurs in patients from their twenties on, regardless of gender. The diagnosis is made based on the symptoms of pain, impaired ranges of motion, and limitation upon climbing stairs. Pain subsides at two weeks but the limitation of physical activity continues and patients lea...

In those who survive the initial impact of aneurysmal subarachnoid hemorrhage (aSAH), delayed ischemic neurological deficit (DIND) is the leading cause of morbidity and mortality. Despite therapeutic advances leading to decreased case fatality rate of 0.9% per year from 1960 to 1992, mainly attributed to improved prevention of rebleeding, the 30-day case fatality rate has remained static, and a...

G T r r a a t g f a W Grassroots advocacy—as the term implies—is a form of advocacy that grows organically and, uite often, spontaneously at the local r regional level. As the leading food nd nutrition experts, registered dititians (RDs) are in a unique position o shape public policy, particularly at he ground level, by participating in a ull spectrum of advocacy activities. “To advance our pro...

Within dual-process accounts of recognition memory, familiarity (as opposed to recollection) is often referred to as a rather automatic and context-free process. Thus, in episodic object recognition, familiarity and its electrophysiological ERP signature are supposed to index prior occurrence of an object independent of the context the object was originally encountered in, e.g., [Ecker, U.K.H.,...

Comprehensive polymorphism data are a prerequisite for the systematic identification of sequence variants affecting phenotypes. In the first part of my talk, I will discuss our efforts to provide a whole genome resource for the study of population level evolutionary processes in an experimentally tractable, multicellular organism, Arabidopsis thaliana. To this end, we have collaborated with Kel...

jahanshahloo has suggested a method for the solving linear programming problems with zero-one variables‎. ‎in this paper we formulate fully fuzzy linear programming problems with zero-one variables and a method for solving these problems is presented using the ranking function and also the branch and bound method along with an example is presented.