Tetracyclines are an old class of molecules that constitute a broad-spectrum antibiotics. Since the first member of tetracycline family were isolated, the clinical importance of these compounds as therapeutic and prophylactic agents against a wide range of infections has stimulated efforts to define their mode of action as inhibitors of bacterial reproduction. We used three SAR methodologies fo...

In today’s knowledge-intensive engineering environment, information management is an important and essential activity. However, existing researches of Engineering Information Management (EIM) mainly focused on numerical data such as computer models and process data. Textual data, especially the case of free texts, which constitute a significant part of engineering information, have been somewha...

The RANS ~Reynolds averaged Navier–Stokes! equations can yield significant error when applied to practical flows involving shock waves. We use the interaction of homogeneous isotropic turbulence with a normal shock to suggest improvements in the k – e model applied to shock/ turbulence interaction. Mahesh et al. @J. Fluid Mech. 334, 353 ~1997!# and Lee et al. @J. Fluid Mech. 340, 22 ~1997!# pre...

The RANS (Reynolds averaged Navier-Stokes) equations can yield significant error when applied to practical flows involving shock waves. We use the interaction of homogeneous isotropic turbulence with a normal shock to suggest improvements in the k− model applied to shock/turbulence interaction. Mahesh et al. and Lee et al. present direct numerical simulation (DNS) and linear analysis of the flo...

The effect of tetrabutylammonium nitrate ([N4444][NO3]) was studied as a surface coating over 1Pd9Ag/Al2O3 and applied in the selective hydrogenation 1,7-octadiene mixture with 1-octene. Weight loadings up to three monolayers (MLs) were investigated further comparison 1-ethylimidazole ([EIM]) carried out assess anionic effects Solid Catalysts an Ionic Liquid Layer (SCILLs). characterised by H2-...

A reexamination of satellite-derived sea surface temperature imagery reveals many examples of Brazil Current rings, both warm and cold, in dipole configurations. The dynamical significance of the dipole model is established by considering the interaction of a cold (cyclonic) eddy with a warm (anticyclonic) ring. The ring is shown to exist as a dipole for about 60 days, or two rotation periods b...

The authors assess the role of time-dependent eddy variability in the Antarctic Circumpolar Current (ACC) in influencing warming of the Southern Ocean. For this, an eddy-resolving quasigeostrophic model of the wind-driven circulation is used, and the response of circumpolar transport, eddy kinetic energy, and eddy heat transport to changes in winds is quantified. On interannual time scales, the...

This paper reports a post-implementation review of usage and user experiences of an electronic information management system (EIM) in a multinational company. The implementation of this system was the ® rst step in the company’s programme to achieve eVective knowledge management leading to innovative and integrated business solutions. In the context of low levels of usage, users were asked to i...