The Bacillus anthracis exotoxin is composed of a lethal factor, a protective antigen, and an edema factor (EF). EF is a calmodulin-dependent adenylate cyclase which elevates cyclic AMP levels within cells. The entire EF gene (cya) has been cloned in Escherichia coli, but EF gene expression by its own B. anthracis promoter could not be detected in E. coli. However, when the EF gene was placed do...

Executive function (EF) has long been considered to be a unitary, domain-general cognitive ability. However, recent research suggests differentiating "hot" affective and "cool" cognitive aspects of EF. Yet, findings regarding this two-factor construct are still inconsistent. In particular, the development of this factor structure remains unclear and data on school-aged children is lacking. Furt...

Most of eukaryotic elongation factor 1 (EF-1) consists of four subunits, EF-la, -/S, -0', and -7, as shown in silk gland, wheat germ (1, 2), Artemia salina (3), and Xenopus laevis (4). EF-la catalyzes the binding of aminoacyl-tRNAs to ribosomes concomitant with the hydrolysis of GTP, while EF-1/3/3'7 catalyzes the exchange of GTP for GDP bound to EF-la subsequent to its release from the ribosom...

Background—Heart failure with preserved ejection fraction (EF) is a common syndrome, but trends in treatments and outcomes are lacking. the proportion of hospitalizations for HF–preserved EF increased from 33% to 39% (PϽ0.0001). In multivariable analyses, use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers at discharge decreased in all EF groups, and ␤-blocker use incr...

Previous work has shown that individual differences in executive function (EF) are predictive of academic skills in preschoolers, kindergartners, and older children. Across studies, EF is a stronger predictor of emergent mathematics than literacy. However, research on EF in children below age three is scarce, and it is currently unknown whether EF, as assessed in toddlerhood, predicts emergent ...

The synthetic curcumin analogue, 3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone (EF-24), suppresses NF-κB activity and exhibits antiproliferative effects against a variety of cancer cells in vitro. Recently, it was reported that EF-24-induced apoptosis was mediated by a redox-dependent mechanism. Here, we studied the effects of N-acetylcysteine (NAC) on EF-24-induced cell death. We also addr...

The tsf genes from Streptomyces coelicolor A3(2) and Streptomyces ramocissimus, encoding the guanine-nucleotide exchange factor EF-Ts, were cloned and sequenced. Streptomycetes have multiple and highly divergent EF-Tu species, with EF-Tu1 and EF-Tu3 showing only about 65% amino acid sequence identity, and yet these can apparently interact with a single EF-Ts species. tsf lies in an operon with ...

UNLABELLED To evaluate myocardial blood flow (MBF) and cardiac function with a single dose of (13)NH(3), electrocardiographically (ECG) gated PET acquisition was performed after a dynamic PET scan was obtained. Gated blood-pool (GBP) imaging with C(15)O PET was also performed to compare the left ventricular ejection fraction (LVEF) obtained using the 2 methods. METHODS Six healthy volunteers ...

BACKGROUND We prospectively followed an ethnically and socioeconomically diverse sample of girls with attention-deficit/hyperactivity disorder (ADHD) (n = 140) and a matched comparison sample (n = 88) from childhood through young adulthood to evaluate developmental trajectories of executive functions (EF) and associations between EF trajectories and dimensional measures of ADHD symptoms. We hyp...

Elongation factor T, (EF-T,) is inactivated by the arginine-specific reagent 2,3-butanedione. Excess elongation factor T, (EF-T,), the protein substrate for EFT,, protects EF-T, from this inactivation. Borate ion affects the inactivation kinetics in a manner consistent with the formation of an arginine residueebutanedione l borate complex. The butanedione inactivation is rapidly reversible in t...