The fundamental objective of dialysis is to maintain the dose of solute clearance and ultrafiltration (UF). When peritoneal dialysis (PD) patients cannot maintain target clearances, the dialysis dose needs to be increased. The means of increasing dose by PD alone are limited, especially in patients with UF failure. Combination therapy with PD and hemodialysis (PD+HD) is the simplest way to solv...

Background. Dialysis dose is commonly defined as a clearance scaled to some measure of body size, but the toxicity of uraemic solutes is probably associated more to their concentrations than to their clearance. Methods. 619 dialysis sessions of 35 patients were modified by computer simulations targeting a constant urea clearance or a constant urea concentration. Results. Urea generation rate G ...

To our knowledge, no studies have examined the role of IL-17 production by neutrophils in immune defense against Mycobacterium tuberculosis (MTB) infection and the pathogenesis of rheumatoid arthritis (RA) caused by MTB infection. Here, we determined that neutrophils express IL-17 in an autocrine IL-6- and IL-23-dependent manner during MTB infection. MTB H37Rv-induced IL-6 production was depend...

Myosin 10 is an actin-based molecular motor that localizes to the tips of filopodia in mammalian cells. To understand how it is targeted to this distinct region of the cell, we have used total internal reflection fluorescence microscopy to study the movement of individual full-length and truncated GFP-tagged molecules. Truncation mutants lacking the motor region failed to localize to filopodial...

Stereochemically pure compounds containing an all carbon quaternary stereocenter based on 1-tetralone, 1-indanone and 4-chromanone scaffolds have been synthesized by employing Lipase PS (Burkholderia cepacia) catalyzed kinetic resolution. These scaffolds are further functionalized by microbial ketoreductase enzymes (Geotrichum candidum, Candida parapsilosis and Aspergillus niger) to access ster...

Covid-19 je infekčn?­ onemocnÄ?n?­, kter?Š zp??soben?Š virem SARS‑CoV-2 (syndrom tÄ??žk?Š respiračn?­ t?­snÄ? koronaviru 2) (1). Celkov?? mortalita n?­zk??: pod 0,5 %. ??mrt?­ jsou p??ev???žnÄ? ve vÄ?kov?Š skupinÄ? nad 60 let a u pacient?? s jin??m tÄ??žk??m chronick??m onemocnÄ?n?­m. VÄ?t??ina nemocn??ch se uzdrav?­ v pr??bÄ?hu jednoho či dvou t??dn??, nicm?ŠnÄ? 5-10 % č??st symptom?...

Let 0 ≤ p ≤ 1/2 and let {0, 1} be endowed with the product measure μp defined by μp(x) = p |x|(1 − p)n−|x|, where |x| = ∑ xi. Let I ⊆ {0, 1} n be an intersecting family, i.e. for every x, y ∈ I there exists a coordinate 1 ≤ i ≤ n such that xi = yi = 1. Then μp(I) ≤ p. Our proof uses measure preserving homomorphisms between graphs. One of the fundamental questions first studied in extremal graph...

The advent of distributed optical fiber sensing technologies has made continuous and dense measurement possible, a very broad application prospect in the field structural health monitoring. However, not all them are able to guarantee accuracy good condition compared traditional sensors, such as FBGs (Fiber Bragg Grating sensor), strain gauges, etc. In our previous study (Cheng et al., 2019) cal...